红金消结胶囊联合醋酸亮丙瑞林治疗子宫内膜异位症临床研究  

Clinical Study on Hongjin Xiaojie Capsules Combined with Leuprorelin Acetate for Endometriosis

作　　者：余晓玲[1] 徐经安 陈荣荣 YU Xiaoling;XU Jing'an;CHEN Rongrong(Department of Gynecology,Anyang Maternal and Child Health Hospital,Anyang Henan 455000,China)

机构地区：[1]安阳市妇幼保健院妇科,河南安阳455000

出　　处：《新中医》2024年第2期100-104,共5页New Chinese Medicine

摘　　要：目的:观察红金消结胶囊联合醋酸亮丙瑞林治疗子宫内膜异位症的临床疗效。方法:选取82例子宫内膜异位症患者,按随机数字表法分为对照组与治疗组各41例。对照组给予注射用醋酸亮丙瑞林缓释微球治疗,治疗组在对照组基础上联合红金消结胶囊联合治疗。比较2组临床疗效与不良反应发生率,以及2组治疗前后中医证候评分、血清糖类抗原125 (CA125)、抗子宫内膜抗体(EMAb)、脂联素(APN)、肝细胞生长因子(HGF)水平、子宫体积、子宫内膜厚度、包块直径。结果:治疗组总有效率为95.12%,对照组为78.05%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分均较治疗前降低(P<0.05),且治疗组中医证候评分低于对照组(P<0.05)。治疗后,2组子宫内膜厚度、子宫体积、包块直径均较治疗前缩小(P<0.05),且治疗组上述3项指标均小于对照组(P<0.05)。治疗后,2组血清CA125、EMAb、HGF水平均较治疗前降低(P<0.05),APN水平较治疗前升高(P<0.05);且治疗组CA125、EMAb、HGF水平低于对照组(P<0.05),APN水平高于对照组(P<0.05)。对照组不良反应发生率为9.76%,治疗组为4.88%,2组比较,差异无统计学意义(P>0.05)。结论:红金消结胶囊联合注射用醋酸亮丙瑞林缓释微球治疗子宫内膜异位症疗效显著,能改善患者临床症状和体征,调节相关血清细胞因子水平,且没有增加药物治疗的不良反应。Objective:To observe the clinical effect of Hongjin Xiaojie Capsules combined with Leuprorelin Acetate for endometriosis.Methods:A total of 82 patients with endometriosis were randomly divided into the control group and the treatment group,with 41 cases in each group.The control group was treated with Leuprorelin Acetate Microspheres Sustained Release for Injection,and the treatment group was supplemented with Hongjin Xiaojie Capsules based on the treatment of the control group.The clinical effects and adverse reaction rates were compared between the two groups.The changes in traditional Chinese medicine(TCM) syndrome scores,levels of carbohydrate antigen 125(CA125),anti endometrial antibody(EMAb),adiponectin(APN) and hepatocyte growth factor(HGF) in serum,the uterine volume,endometrial thickness and mass diameter were compared before and after treatment.Results:The total effective rate was 95.12% in the treatment group,and 78.05% in the control group,the difference being significant(P<0.05).After treatment,the TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score in the treatment group were lower than those in the control group(P<0.05).After treatment,the endometrial thickness,uterine volume and mass diameter in the two groups were decreased when compared with those before treatment(P<0.05),and the above three indexes in the treatment group were smaller than that in the control group(P<0.05).After treatment,the levels of CA125,EMAb,and HGF in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of APN were increased when compared with those before treatment(P<0.05);the levels of CA125,EMAb and HGF in serum in the treatment group were lower than those in the control group(P<0.05),and the level of APN was higher than that in the control group(P<0.05).The incidence of adverse reactions was 9.76% in the control group,and 4.88% in the treatment group,there being no significant difference betw

关 键 词：子宫内膜异位症 红金消结胶囊 注射用醋酸亮丙瑞林缓释微球 中医证候评分 糖类抗原125 抗子宫内膜抗体 

分 类 号：R711.71[医药卫生—妇产科学]