基于数据挖掘探讨滇女金丸治疗卵巢功能早衰及其相关卵巢疾病的临床可行性  

Exploration of the Clinical Feasibility on Diannvjin Pills in Treating Premature Ovarian Failure and Related Ovarian Diseases Based on Data Mining

作　　者：冯晓军[1] 邱月 李江月 孙伟[1] FENG Xiaojun;QIU Yue;LI Jiangyue;SUN Wei(The Second Affiliated Hospital of Shandong University of Chinese Medicine,Jinan Shandong 250001,China;Department of Clinical Pharmacology,West China Hospital of Sichuan University,Chengdu Sichuan 610041,China;Hongwing Pharma Group Co.,LTD.,Chengdu Sichuan 610041,China)

机构地区：[1]山东中医药大学第二附属医院,山东济南250001 [2]四川大学华西医院临床药学部,四川成都610041 [3]红云制药集团股份有限公司,四川成都610041

出　　处：《新中医》2024年第2期170-176,共7页New Chinese Medicine

摘　　要：目的:通过数据挖掘方法探讨滇女金丸治疗卵巢功能早衰及其相关卵巢疾病的临床可行性。方法:检索中国知网、万方等文献数据库,收集、整理具有临床数据支撑治疗卵巢功能早衰及其相关疾病的中药方剂文献资料,对文献中的中药方剂进行药材频次、性味、归经、药效分类、关联规则Apriori分析,分析文献方剂治疗卵巢功能早衰及其相关疾病的用药特点及规律,并与滇女金丸的处方特点进行比较、分析。结果:滇女金丸处方特点与治疗卵巢功能早衰及其相关疾病的文献方剂用药特点及规律基本一致,文献方剂中药材使用频次最高的熟地黄、当归为滇女金丸的君药,方剂中药材性味、归经、药效分类各占比与滇女金丸处方药材占比相似,Apriori分析显示,滇女金丸常用药对配伍与文献方剂相近。结论:滇女金丸在治疗卵巢功能早衰及其相关卵巢疾病方面具有一定的临床可行性。Objective:To explore the clinical feasibility of Diannvjin Pills in the treatment of premature ovarian failure and related ovarian diseases by data mining method.Methods:Literature databases such as CNKI and Wanfang were searched to collect and collate literature materials of traditional Chinese medicine(TCM) prescriptions with clinical data to support the treatment of premature ovarian failure and related diseases.The frequency,property and flavor,meridian tropism,efficacy classification and association rule Apriori were analyzed for the TCM prescriptions in the literature.The characteristics and rules of the prescription used in the treatment of premature ovarian failure and related diseases were analyzed,and the prescription characteristics were compared with those of Diannvjin Pills.Results:The prescription characteristics and rules of Diannvjin Pills are basically consistent with those of the literature on the treatment of premature ovarian function failure and related diseases.Rehmanniae Radix Praeparata and Angelicae Sinensis Radix,which were used most frequently in the literature,were the chief medicinals of Diannvjin Pills,and the proportion of the classification property,flavor,meridian tropism and the efficacy of the prescription herbs was similar to those of Diannvjin Pills.Apriori analysis showed that,the compatibility of DiannvJin Pills was similar to that of the prescriptions in the literature.Conclusion:Diannvjin Pills has certain clinical feasibility in the treatment of premature ovarian failure and related ovarian diseases.

关 键 词：卵巢功能早衰 卵巢疾病 滇女金丸 数据挖掘 临床可行性 

分 类 号：R711.75[医药卫生—妇产科学]