多药耐药相关蛋白转运体在药物性肝损伤中的作用研究进展  

The role of MRPs transporters in drug-induced liver injury

作　　者：王欣[1] 史磊磊 张雨涵 谢允东 刘继平[1] WANG Xin;SHI Leilei;ZHANG Yuhan;XIE Yundong;LIU Jiping(Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046

出　　处：《中国药物警戒》2024年第2期229-234,共6页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(82204790)。

摘　　要：肝脏是人体新陈代谢最旺盛的器官,也是体内多种药物的解毒器官。当长期或过量使用药物时会增加药物性肝损伤(DILI)的风险。多药耐药相关蛋白(MRPs)是位于细胞膜上的功能蛋白,可转运多种药物,在DILI中发挥重要作用。MRPs功能的抑制、缺失是药物肝毒性产生的重要原因。本文对MRPs的结构、表达部位及功能进行归纳,并对MRPs与DILI的关系及其改善DILI的机制进行总结,期望更好地了解MRPs转运体与DILI的关系,为后续防治DILI提供参考。The liver is the organ with the most active metabolic activity in the human body,and is also responsible for the detoxification of numerous drugs.Prolonged or excessive use of drugs may lead to drug-induced liver injury(DILI),making drug transporters a key area of investigation in DILI research.Multidrug resistance-associated-proteins(MRPs)are proteins found on the cell membrane and are responsible for multidrug resistance.They are capable of transporting multiple drugs and play important role in DILI.Inhibition and removal of drug transporter activity is a major contributor to drug-induced liver damage.This article concludes and integrates the structure,expression sites,and functions of MRPs,and summarizes the relationship between MRPs and DILI,as well as the mechanisms for improving DILI In order to better understand the relationship between MRPs transporters and DILI,and provide reference for the prevention and treatment of DILI in the future.

关 键 词：多药耐药相关蛋白 药物性肝损伤 核因子相关受体 转运 

分 类 号：R994.11[医药卫生—毒理学]