重楼抗肿瘤活性成分分类及作用机制研究进展  

Classification of anti-tumor active ingredients of Paridis Rhizoma and research progress in mechanisms of action

作　　者：辛灵怡 杨洋 朱婧 何娜 张静媚[1,2] 王航天 陈琴华 杨光义 XIN Lingyi;YANG Yang;ZHU Jing;HE Na;ZHANG Jingmei;WANG Hangtian;CHEN Qinhua;YANG Guangyi(Department of Pharmacy,Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Shenzhen Guangdong 518000,China;Key Laboratory of TCM Clinical Pharmacy,Shenzhen Bao’an Authentic TCM Therapy Hospital,Shenzhen Guangdong 518000,China;Department of Pharmacy,Shenzhen Bao’an Chinese Medicine Hospital,Guangzhou University of Chinese Medicine,Shenzhen Guangdong 518102,China)

机构地区：[1]深圳市中西医结合医院药剂科,广东深圳518000 [2]广州中医药大学第七临床医学院,广东深圳518000 [3]深圳市宝安纯中医治疗医院药学部,广东深圳518102

出　　处：《中国药物警戒》2024年第2期235-240,共6页Chinese Journal of Pharmacovigilance

基　　金：广东省中医药局项目(20221340);深圳市科技创新委员会基础研究面上项目(JCYJ20210324142012033);深圳市‘医疗卫生三名工程’项目资助(SZZYSM202106004)。

摘　　要：重楼是清热解毒传统中药。重楼皂苷是重楼最主要的抗肿瘤活性成分,包括50多种化合物,其中具有抗肿瘤作用的成分为重楼皂苷Ⅰ、Ⅱ、Ⅱ、Ⅶ等,对于治疗多种癌症效果显著,如肝癌、结肠癌、脑瘤、大肠癌、食管癌、肺癌、鼻咽癌等。这些成分主要是异螺甾烷醇型甾体皂苷类成分,以重楼皂苷Ⅰ含量最多,其次有重楼皂苷Ⅱ、薯蓣皂苷、重楼皂苷A、纤细薯蓣皂苷、重楼皂苷Ⅵ、重楼皂苷Ⅶ、重楼皂苷H、重楼皂苷E等。近年来,重楼皂苷抗肿瘤作用逐渐被发现并应用到临床中,但重楼皂苷不良反应也有报道,如重楼皂苷Ⅰ对肝脏的毒性损伤等。本文对重楼中的皂苷类成分进行分类并综述异螺甾烷醇型皂苷抗肿瘤作用机制的最新研究进展,以总结重楼皂苷抗肿瘤作用的活性成分及作用机制,为进一步研究重楼皂苷抗肿瘤作用及安全用药提供参考。Paridis Rhizoma is a traditional Chinese medicine for clearing away heat and toxic materials.Polyphyllin,as the most important anti-tumor active ingredient of Paridis Rhizoma,contains more than 50 types of compounds,among which the ingredients with anti-tumor effects are polyphyllin I,II,VI,VII.It is effective in treating many types of tumor cancers,such as liver cancer,colon cancer,brain tumor,colorectal cancer,esophageal cancer,lung cancer and nasopharyngeal carcinoma.These ingredients are mostly isospirostanol saponins,dominated by polyphyllin I,followed by polyphyllin II,diosgenin,polyphyllin A,gracillin,polyphyllin VI,polyphyllin VII,polyphyllin H and polyphyllin E.In recent years,the anti-tumor effects of polyphyllin have been gradually discovered and applied in clinic,but the adverse effects of Paris saponins have also been reported,such as the toxic damage of polyphyllin I to the liver.In this paper,the saponin components in Paridis Rhizoma are classified while the latest progress in research on the anti-tumor mechanism of isospirostanol saponins is reviewed in order to summarize the active components and mechanism of action of the antitumor effect of Paris saponins and to provide reference for studies on anti-tumor effects of polyphyllin and the safety of medication.

关 键 词：重楼 重楼皂苷 抗肿瘤 异螺甾烷醇型 活性成分 作用机制 

分 类 号：R979.1[医药卫生—药品]