Effects of Bisphenol A and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice  

作　　者：MENG Li Ying TAO Wen Fu LI Jing ZHU Min ZHONG De Bin ZHOU Jing QIN Xue WEI Rong Guo 

机构地区：[1]Department of Clinical Laboratory,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China [2]Department of Clinical Laboratory,The Fifth Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China [3]Jiangsu Key Laboratory of Environmental Engineering,Jiangsu Academy of Environmental Sciences,Nanjing 210000,Jiangsu,China

出　　处：《Biomedical and Environmental Sciences》2024年第1期19-30,共12页生物医学与环境科学（英文版）

基　　金：supported by the Open Fund of the State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences [No. KF2020-13];Guangxi Zhuang Autonomous Region Health and Family Planning Commission Self-Financed Scientific Research Project [No.Z20200208, Z-A20221124];Guangxi Medical and Health Key Discipline Construction Project (No. Department of Clinical Laboratory)。

摘　　要：Objective The aim of this study was to assess the impact of bisphenol A(BPA)and its substitute,bisphenol F(BPF),on the colonic fecal community structure and function of mice.Methods We exposed 6–8-week-old male C57BL/6 mice to 5 mg/(kg∙day)and 50μg/(kg∙day)of BPA or BPF for 14 days.Fecal samples from the colon were analyzed using 16S rRNA sequencing.Results Gut microbiome community richness and diversity,species composition,and function were significantly altered in mice exposed to BPA or BPF.This change was characterized by elevated levels of Ruminococcaceae UCG-010 and Oscillibacter and decreased levels of Prevotella 9 and Streptococcus.Additionally,pathways related to carbohydrate and amino acid metabolism showed substantial enrichment.Conclusion Mice exposed to different BP analogs exhibited distinct gut bacterial community richness,composition,and related metabolic pathways.Considering the essential role of gut bacteria in maintaining intestinal homeostasis,our study highlights the intestinal toxicity of BPs in vertebrates.

关 键 词：Bisphenol A(BPA) Bisphenol F(BPF) 16S rRNA MICROBIOTA 

分 类 号：R114[医药卫生—卫生毒理学]