白芍及白芍总苷治疗自身免疫性皮肤病的作用及机制研究进展  

Research progress of effects and mechanisms of paeony and total glucosides of paeony in treatment of immune-associated dermatoses

作　　者：杨阳[1] 陈睿轩 闵力 马致洁[4] 梅雪岭[1,5] Yang Yang;Chen Ruixuan;Min Li;Ma Zhijie;Mei Xueling(Department of Education,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;School of Pharmacy,Shanxi Medical University,Taiyuan 030001,China;Department of Gastroenterology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Pharmacy,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Dermatology and Venereology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院教育处,北京100050 [2]山西医科大学药学院,太原030001 [3]首都医科大学附属北京友谊医院消化内科,北京100050 [4]首都医科大学附属北京友谊医院药学部,北京100050 [5]首都医科大学附属北京友谊医院皮肤性病科,北京100050

出　　处：《首都医科大学学报》2024年第1期1-7,共7页Journal of Capital Medical University

基　　金：首都卫生发展科研专项项目(首发2022-2-20212)。

摘　　要：药理研究表明白芍具有抗炎、免疫调节、保肝、镇痛等作用,在临床上白芍及白芍总苷常用于治疗自身免疫性疾病。随着白芍及白芍总苷在抗炎和免疫调节中的作用机制逐步被认识,它们在免疫相关性、炎症性皮肤病中的临床应用得到了不断扩展,通过抗炎、免疫调节和抗氧化等机制在增效减毒、降低疾病复发率方面发挥重要作用。本文对白芍及白芍总苷治疗免疫相关性、炎症性皮肤病的作用及机制的研究进展进行综述,为其深入研究提供依据。Pharmacological studies have shown that white paeony has anti-inflammatory,immunomodulatory,hepatoprotective,and analgesic effects.In clinical practice,paeony and total glucosides of paeony are often used to treat autoimmune diseases.As the anti-inflammatory,immune-modulating and anti-oxidizing mechanisms of paeony and total glucosides of paeony are gradually understood,their clinical applications in immune-related and inflammatory skin diseases have been continuously expanded.The mechanisms such as anti-oxidation play an important role in enhancing efficacy,attenuating toxicity,and reducing disease recurrence rates.This article reviews the research progresses on the effects and mechanisms of paeony and total glucosides of paeony in the treatment of immune-related and inflammatory skin diseases,to provide a basis for in-depth research.

关 键 词：白芍 白芍总苷 自身免疫性皮肤病 机制研究 

分 类 号：R75[医药卫生—皮肤病学与性病学]