Mn(acac)_(3)诱导1-异腈基-2-[1-(三氟甲基)乙烯基]苯自由基环化合成4-三氟甲基喹啉衍生物  

Manganese-induced Radical Cyclization of 1-Isocyano-2-[1-(trifluoromethyl)ethenyl]benzenes to Access 4-CF_(3)-Quinoline Derivatives

作　　者：姚团利 汪珂 朱双 李涛 YAO Tuanli;WANG Ke;ZHU Shuang;LI Tao(Key Laboratory of Chemical Additives for China National Light Industry,College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology,Xi’an 710021,China)

机构地区：[1]陕西科技大学化学与化工学院,中国轻工业轻化工助剂重点实验室,西安710021

出　　处：《高等学校化学学报》2024年第3期84-93,共10页Chemical Journal of Chinese Universities

基　　金：国家重点研发计划项目(批准号:2018YFE01962600);上海市科技兴农重点攻关项目(批准号:T20200104)资助.

摘　　要：开发了一种新的由锰[Mn(Ⅲ)/Mn(Ⅱ)]催化1-异腈基-2-[1-(三氟甲基)乙烯基]苯与芳基硼酸的自由基6-endo-trig环化反应.该反应条件温和,可在没有任何外部氧化剂、配体或添加剂的情况下,得到各种高区域选择性和化学选择性的4-三氟甲基-2-芳基喹啉衍生物.A new Mn(Ⅲ)/Mn(Ⅱ)induced reaction was developed,which involves a radical 6-endo-trig cyclization of 1-isocyano-2-[1-(trifluoromethyl)vinyl]benzene with arylboronic acid and catalyzed by manganese.Various 4-CF_(3)-2 arylquinolines were obtained with high regioselectivity,chemical selectivity and mild condition without any exter-nal oxidants,ligands,or additives.

关 键 词：三乙酰丙酮锰诱导 异腈 苯硼酸 4-三氟甲基喹啉 

分 类 号：O626[理学—有机化学]