柱撑壳聚糖的氢键密堆积结构制备生物安全的高性能保润材料  

Pillaring Hydrogen Bonded Dense Structures of Chitosan for the Biosafe High-performance Humectant

作　　者：高楠 郑悦 李欢欢 臧婉辰 元野[1] 杨亚杰 金哲 GAO Nan;ZHENG Yue;LI Huanhuan;ZANG Wanchen;YUAN Ye;YANG Yajie;JIN Zhe(Key Laboratory of Polyoxometalate and Reticular Material Chemistry,Ministry of Education,Faculty of Chemistry,Northeast Normal University,Changchun 130024,China)

机构地区：[1]东北师范大学化学学院,多酸与网格材料化学教育部重点实验室,长春130024 [2]吉林烟草工业有限责任公司技术研发中心

出　　处：《高等学校化学学报》2024年第3期136-142,共7页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:52204389);中国博士后科学基金(批准号:2023T160261);中央高校基础研究基金(批准号:2412023YQ001)资助.

摘　　要：保润剂材料内部含有大量亲水基团,能够增加或长期保持物质的含水量,在医疗保健、食品、化妆品和药品等领域应用广泛.壳聚糖分子具有可生物降解、无毒及抗菌等多种优点,是一种高性能的保润剂.然而,其链中存在多个氢键,这种氢键密堆积结构导致水分子无法储存在颗粒内部,严重削弱了材料的吸水和储水能力.本文采用共价偶联方法,使苯甲酸与壳聚糖发生脱水聚合反应.疏水性苯基结构单元能够将亲水性的柔性链进行柱撑,从而形成水分子的存储空间.基于这种独特的设计,制得材料的比表面积比原来的壳聚糖提高了9倍多,吸水能力也相应提高了3倍多.安全性测试结果表明,小鼠在口服壳聚糖基多孔保润剂后,蛋白质水平均无明显变化,证实了壳聚糖基多孔保润剂没有生物毒性.将壳聚糖多孔保润材料均匀分布在试纸上后,试纸的失水量比商用丙二醇分布的试纸减少了20%.Humectants with a large number of hydrophilic groups are able to increase or maintain the water content of a substance for a long time,which possess a huge range of applications in industries including medical care,food,cosmetic products,and medicinal herbs.Chitosan molecules featuring a variety of advantages of biodegradability,non-toxicity,anti-bacterial,etc,are investigated to be a high-performance humectant.Nevertheless,the dense structure originated from multiple hydrogen bonds leads to the inability of water molecules to access in the interior of the particles,which seriously depresses the material’s ability to absorb and store water.In this paper,a covalent coupling approach was adopted to react benzoic acid with chitosan through a dehydration polymerization reaction.The hydrophobic phenyl units are able to columnarize the hydrophilic chitosan chains,forming a large-volume space for the storage of the water molecules.Based on this,the specific surface area of the as-prepared material is enhanced by about 1000%compared to the original chitosan;correspondingly the water-absorption capacity has been increased by about 400%.At the same time,cellular safety tests have shown that the chitosan-based porous humectant possesses good biosafety properties.After uniformly distributed on top of the damping papers,the amount of water loss of the paper is improved by 20%compared to the commercial humectant,propylene glycol.

关 键 词：多孔材料 壳聚糖 保润剂 保水性能 氢键 

分 类 号：O631[理学—高分子化学]