2-(甲氧基亚胺基)苯乙酸的合成研究  

Study on Synthesis of 2-(Methoxyimino) Phenyl Acetic Acid

作　　者：孟悦宁 王彩平 李飞[1] MENG Yue-ning;WANG Cai-ping;LI Fei(School of Petrochemical Engineering,Liaoning Petrochemical University,Fushun Liaoning 113001,China;Ningbo Institute of Dalian University of Technology,Ningbo Zhejiang 315016,China;Beijing Winsunny Pharmaceutical Co.,Ltd.,Beijing 101113,China)

机构地区：[1]辽宁石油化工大学石油化工学院,辽宁抚顺113001 [2]大连理工大学宁波研究院,浙江宁波315016 [3]北京福元医药股份有限公司,北京101113

出　　处：《当代化工》2024年第1期111-114,共4页Contemporary Chemical Industry

基　　金：辽宁省重点研发计划项目(项目编号:2019JH2/10100005)。

摘　　要：研究了2-(甲氧基亚胺基)苯乙酸即苯基MIA的合成,并对该工艺的反应条件进行了筛选和优化。将甲氧基胺基盐酸盐和碳酸钠固体分别加入圆底烧瓶中,溶于干燥的二氯甲烷,0℃下加入苯甲酰甲酸,25℃下反应3h。该工艺方法得到72%左右的收率,且反应条件简单温和,工艺设备成本廉价,实现了操作简单、经济实惠和绿色环保的目的。The synthesis of 2-(methoxyimino) phenylacetic acid(phenyl MIA) was studied,the reaction conditions of the process were screened and optimized.A solution of methoxy ammonium chloride and Na_2CO_(3) were added to a round-bottomed flask,and then benzoyl formic acid in dry DCM was added at 0 ℃.The mixture was stirred at 25 ℃for 3 h.The yield of this process was about 72%,the reaction conditions were simple,mild and the cost of process equipment was cheap.The process method realized the purpose of simple operation,economic benefit and environmental protection.

关 键 词：甲氧基肟导向基团 碳氢键活化 过渡金属催化 合成 

分 类 号：TQ225.26[化学工程—有机化工]