外泌体作为诊断结核分枝杆菌感染的标志物研究  

Exosomes as Potential Markers for Diagnosis of Mycobacterium tuberculosis Infection

作　　者：王楠 吴建红[1] 李玉洁 郑志焕 姚丽洪 王建军[1] WANG Nan;WU Jianhong;LI Yujie;ZHENG Zhihuan;YAO Lihong;WANG Jianjun(Department of Laboratory Medicine,Kunshan Hospital Affiliated to Jiangsu University,Kunshan 215300,Jiangsu,China;College of Clinical and Basic Medicine,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250000,Shandong,China;Changchun Center for Disease Control and Prevention,Changchun 130000,Jilin,China)

机构地区：[1]江苏大学附属昆山医院检验科,中国江苏昆山215300 [2]山东第一医科大学(山东省医学科学院)临床与基础医学院,中国山东济南250000 [3]长春市疾病预防控制中心,中国吉林长春130000

出　　处：《生命科学研究》2024年第1期33-40,共8页Life Science Research

基　　金：国家自然科学基金青年科学基金项目(82002111)。

摘　　要：外泌体(exosome)是一种直径为30~150 nm的囊泡状物质,其通过携载脂质、蛋白质、m RNA和非编码RNA等多种生物活性物质在机体的免疫调节过程以及细胞间的信息传递发挥至关重要的作用。近年来,越来越多的研究发现外泌体积极地参与了结核分枝杆菌感染的发生与发展。外泌体成分作为结核病感染的潜在标志物,拥有特异性强、稳定性好等特点,在结核病的诊断、疗效评估、预后监测中发挥重要的作用。本文针对外泌体作为结核病诊断标志物的价值,及在结核病中的潜在作用进行综述,为其作为诊断标志物提供理论基础。Exosomes are vesicular structures with a diameter of 30~150 nm,and play critical roles in immune regulation and intercellular communication by carrying various bioactive substances such as lipids,proteins,mRNAs,and non-coding RNAs.In recent years,accumulating studies have revealed that exosomes actively participate in the occurrence and development of Mycobacterium tuberculosis infection.Moreover,exosomal components,as potential biomarkers of M.tuberculosis infection,have the characteristics of strong specificity and good stability,and play an important role in diagnosis,therapeutic efficacy evaluation,and prognosis of tuberculosis.Herein,the values of exosomes as diagnostic markers and their potential roles in tuberculosis are reviewed,aiming to provide a theoretical basis for their application as diagnostic biomarkers.

关 键 词：外泌体 结核分枝杆菌 标志物 诊断 

分 类 号：Q25[生物学—细胞生物学] R52[医药卫生—内科学]