m^(6)A修饰调控细胞自噬参与雄性生殖疾病研究进展  

Research Progress of m^(6)A Modification Regulating Autophagy in Male Reproductive Diseases

作　　者：彭芃 戚星宇 袁峥嵘[1] 马毅[2] PENG Peng;QI Xingyu;YUAN Zhengrong;MA Yi(College of Biological Sciences and Technology,Beijing Forestry University,Beijing 100083,China;Tianjin Academy of Agricultural Sciences Animal Husbandry and Veterinary Institute,Tianjin 300384,China)

机构地区：[1]北京林业大学生物科学与技术学院,中国北京100083 [2]天津市农业科学院畜牧兽医研究所,中国天津300384

出　　处：《生命科学研究》2024年第1期41-47,70,共8页Life Science Research

摘　　要：N^(6)-甲基腺苷(N^(6)-methyladenosine, m^(6)A)修饰是在腺苷核苷酸N^(6)位置上发生的甲基化,在多种RNA代谢过程如m RNA剪接、翻译、运输、降解中发挥关键作用,进而对各种生命过程产生广泛影响。细胞自噬是真核细胞在自噬相关基因的调控下通过溶酶体对自身细胞质蛋白质和受损细胞器进行降解的过程。本文总结了m^(6)A修饰调控细胞自噬在雄性生殖疾病发生发展过程中的研究进展,旨在为今后m^(6)A修饰调节自噬水平在雄性生殖中的调控机理研究提供参考资料,为雄性生殖疾病的治疗策略提供新方向。N^(6)-Methyladenosine(m^(6)A)modification is methylation of adenosine nucleotides at the N^(6) position in RNA molecules.It plays a pivotal role in various pathways of RNA metabolism such as mRNA splicing,translation,transportation,and degradation,widely affecting life processes.Autophagy is a natural process in which eukaryotic cells use lysosomes to degrade cytoplasmic proteins and damaged organelles under the regulation of autophagy-related genes.Herein,the research progress of m^(6)A modification in regulating autophagy in the occurrence and development of male reproductive diseases was summarized.It aimed to provide reference materials for studing the regulatory mechanisms of male reproduction through autophagy level regulation by m^(6)A modification,and offer novel therapeutic strategies for treatment of male reproductive diseases.

关 键 词：N^(6)-甲基腺苷(m^(6)A)修饰 RNA修饰 细胞自噬 雄性生殖疾病 男性不育 

分 类 号：Q75[生物学—分子生物学] R697[医药卫生—泌尿科学]