成人吸入性一氧化氮治疗及其临床应用进展  

Progress on the treatment and clinical application of inhaled nitric oxide in adults

作　　者：丁悦加 贾建伟 葛慧青[1] Ding Yuejia;Jia Jianwei;Ge Huiqing(Department of Respiratory Therapy,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院呼吸治疗科,杭州310016

出　　处：《国际呼吸杂志》2024年第1期110-114,共5页International Journal of Respiration

基　　金：国家自然科学基金(82070087)。

摘　　要：一氧化氮是血管内皮细胞产生的天然血管扩张因子。目前吸入性一氧化氮(iNO)已获批用于新生儿持续性肺动脉高压治疗,而对于成人患者,iNO治疗已在右心导管术期间急性肺血管反应试验中被证实有明确作用。近年来随着对iNO研究的深入,更多的疾病能从iNO治疗中获益。本文就iNO的作用机制及其相关临床应用进展作一综述,以进一步加深对iNO的生理效应及其在成人中临床应用效果的了解。Nitric oxide is a natural vasodilator produced by vascular endothelial cells.Inhaled nitric oxide(iNO)is currently approved for the treatment of persistent pulmonary hypertension of the newborn.In adults,iNO therapy has been validated for its definite efficacy on acute pulmonary vascular response testing during right heart catheterization.In recent years,with the deepening of iNO research,iNO therapy has been able to benefit various diseases.This article reviewes the mechanism of iNO and its related clinical applications,thus further deepening the understanding of its physiological effects of iNO and clinical application in adults.

关 键 词：一氧化氮 吸入性一氧化氮 血管扩张因子 生理效应 临床应用 

分 类 号：R56[医药卫生—呼吸系统]