运动调控尿酸的作用机制  

Mechanism by which exercise controls uric acid level

作　　者：吴昱苇 朱江 郑兵 吴宗辉 Wu Yuwei;Zhu Jiang;Zheng Bing;Wu Zonghui(School of Physical Education,Southwest University,Chongqing 400715,China;Sports Rehabilitation Institute of Southwest University,Chongqing 400715,China;Southwest University Hospital,Chongqing 400715,China)

机构地区：[1]西南大学体育学院,重庆市400715 [2]西南大学运动康复研究所,重庆市400715 [3]西南大学医院,重庆市400715

出　　处：《中国组织工程研究》2024年第34期5552-5557,共6页Chinese Journal of Tissue Engineering Research

基　　金：重庆市中医药重点建设学科项目(2021-4322190044),项目负责人:吴宗辉;重庆市体育科研项目(C202125),项目负责人:吴宗辉。

摘　　要：背景:体内尿酸积累过多会导致高尿酸血症和痛风等疾病,是心血管和肾功能障碍的危险因素。国内外多个运动医学组织机构都倡导制定运动处方来防治慢性疾病,然而在预防和治疗高尿酸血症的实践中此方法尚未得到有效开展。目的:以综述高尿酸血症形成和运动对尿酸的调控及相关机制为基础,凝练出适合大众化运动预防和辅助治疗高尿酸血症的方案,提出不同高尿酸血症阶段患者运动时的注意事项。方法:以“尿酸,痛风,有氧运动,力量训练,高强度间歇训练,肥胖”为中文检索词,以“uric acid,gout,aerobic exercise,strength training,high-intensity interval training,obesity”为英文检索词,分别检索PubMed数据库和中国知网数据库,搜寻各数据库建库至2023年10月发表的所有研究。通过阅读文题和摘要进行初步筛选,排除重复性研究及内容不相关的文献,最后纳入64篇文献进行综述。结果与结论:高尿酸血症的形成由肝脏合成尿酸过多、肾脏肾外排泄不足或二者共同导致。运动可通过调节抗氧化酶活性、尿酸排泄蛋白的表达、脂代谢途径来改善体内的尿酸水平,有氧运动、力量训练、高强度间歇等运动可有效调节尿酸水平、减轻炎症反应、促进尿酸排泄蛋白的表达和脂代谢,达到预防和治疗高尿酸血症的效果。目前,关于运动对尿酸水平直接调节机制的研究尚显不足,未来的研究需要更加深入地探索运动对尿酸水平调节的可能机制,并且细化不同运动方式对不同特征高尿酸血症患者的影响。BACKGROUND:Excessive accumulation of uric acid in the body can lead to diseases such as hyperuricemia and gout,which is a risk factor for cardiovascular and renal dysfunction.Many sports medicine organizations at home and abroad advocate the formulation of exercise prescription to prevent and treat chronic diseases,but this method has not been effectively carried out in the prevention and treatment of hyperuricemia.OBJECTIVE:Based on an overview of the formation of hyperuricemia and the regulation of uric acid by exercise and its related mechanisms,to condense a program suitable for popular exercise to prevent and assist in the treatment of hyperuricemia,and to propose precautions to be taken when exercising for patients with different stages of hyperuricemia.METHODS:PubMed and CNKI were searched for relevant literature published before October 2023 using the keywords of“uric acid,gout,aerobic exercise,strength training,high-intensity interval training,obesity”in English and Chinese,respectively.Initial screening was done by reading the titles and abstracts to exclude repetitive studies and literature with irrelevant content,and finally 64 papers were included for review.RESULTS AND CONCLUSION:The formation of hyperuricemia is caused by excessive synthesis of uric acid by the liver,insufficient excretion by the kidneys,or both.Exercise can improve the uric acid level in the body by regulating the activity of antioxidant enzymes,the expression of uric acid excretion protein and lipid metabolism.Aerobic exercise,strength training,high-intensity intermittent exercise can effectively regulate uric acid levels,reduce inflammation,promote the expression of uric acid excretion protein and lipid metabolism,and achieve good results in the prevention and treatment of hyperuricemia.Currently,there is a lack of research on the mechanisms underlying direct regulation of uric acid levels by exercise,and future studies need to explore in greater depth the possible mechanisms of regulation of uric acid levels by exercise and

关 键 词：高尿酸血症 痛风 运动 尿酸 炎症反应 尿酸排泄蛋白 脂代谢 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R-1