凝血酶原时间与血小板参数检验对肝硬化患者肝损伤情况的评估作用  

Assessment role of prothrombin time and platelet parameter test on liver injury in patients with cirrhosis

作　　者：许岩岩 XU Yanyan(Luoyang Dongfang People's Hospital,Luoyang 471003,China)

机构地区：[1]洛阳市东方人民医院,河南洛阳471003

出　　处：《临床医学研究与实践》2024年第8期93-96,共4页Clinical Research and Practice

摘　　要：目的分析凝血酶原时间(PT)与血小板参数检验对肝硬化患者肝损伤情况的评估作用。方法回顾性分析我院2021年7月至2022年12月收治的60例肝硬化患者的临床资料,以肝损伤程度为标准将其分为有出血组(有出血症状,19例)和无出血组(无出血症状,41例)。比较两组的凝血指标、血小板参数及肝功能指标。结果有出血组的凝血酶时间(TT)、PT、活化部分凝血活酶时间(APTT)均显著长于无出血组,纤维蛋白原(FIB)水平显著低于无出血组,差异具有统计学意义(P<0.05)。有出血组的血小板计数(PLT)、血小板压积(PCT)显著低于无出血组,平均血小板体积(MPV)、血小板分布宽度(PDW)显著高于无出血组,差异具有统计学意义(P<0.05)。有出血组的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(GGT)水平均显著高于无出血组,白蛋白(ALB)水平显著低于无出血组,差异具有统计学意义(P<0.05)。结论PT与血小板参数检验可有效评估肝硬化患者肝损伤情况,为患者的疾病诊断和治疗方案制定提供依据。Objective To analyze the assessment role of prothrombin time(PT)and platelet parameter test on liver injury in patients with cirrhosis.Methods The clinical data of 60 patients with cirrhosis admitted in our hospital from July 2021 to December 2022 were retrospectively analyzed.According to the degree of liver injury,the patients were divided into bleeding group(19 patients with bleeding symptoms)and non-bleeding group(41 patients without bleeding symptoms).The coagulation indexes,platelet parameters and liver function indexes of the two groups were compared.Results The thrombin time(TT),PT and activated partial thromboplastin time(APTT)of the bleeding group were significantly longer than those of the non-bleeding group,the fibrinogen(FIB)level was significantly lower than that of the non-bleeding group,and the differences were statistically significant(P<0.05).The platelet count(PLT)and plateletcrit(PCT)of the bleeding group were significantly lower than those of the non-bleeding group,and the mean platelet volume(MPV)and platelet distribution width(PDW)were significantly higher than those of the non-bleeding group,and the differences were statistically significant(P<0.05).The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and γ-glutamyltranspeptidase(GGT)in the bleeding group were significantly higher than those in the non-bleeding group,and the level of albumin(ALB)was significantly lower than that in the non-bleeding group,and the differences were statistically significant(P<0.05).Conclusion The PT and platelet parameter test can effectively evaluate the liver injury in patients with cirrhosis,and provide basis for disease diagnosis and treatment plan formulation of patients.

关 键 词：肝硬化 凝血酶原时间 血小板参数 肝功能指标 生化检验 肝损伤程度 

分 类 号：R446[医药卫生—诊断学]