阿奇霉素联合头孢哌酮舒巴坦治疗小儿细菌性肺炎的效果分析  

Effect Analysis of Azithromycin Combined with Cefoperazone Sulbactam in Treatment of Pediatric Bacterial Pneumonia

作　　者：刘毅坚[1] 周林[1] 徐芸[1] Liu Yijian;Zhou Lin;Xu Yun(PediatricDepartment,BeijingFengtaiHospital,Beijing 100071,China)

机构地区：[1]北京丰台医院儿科,北京100071

出　　处：《中国社区医师》2024年第2期10-12,共3页Chinese Community Doctors

摘　　要：目的:分析阿奇霉素联合头孢哌酮舒巴坦治疗小儿细菌性肺炎的效果。方法:选取2017年2月—2023年2月北京丰台医院收治的66例细菌性肺炎患儿作为研究对象,根据随机数字表法分为观察组和对照组,各33例。两组均给予常规治疗,对照组在常规治疗基础上给予头孢哌酮舒巴坦治疗,观察组在对照组基础上给予阿奇霉素治疗。比较两组症状体征持续时间、胸部CT病灶持续时间、住院时间、D-二聚体(D-D)水平和炎性因子水平。结果:观察组发热持续时间、喘息持续时间、咳嗽持续时间、肺部啰音持续时间、胸部CT病灶持续时间及住院时间短于对照组,差异有统计学意义(P<0.001)。治疗前,两组D-D、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平比较,差异无统计学意义(P>0.05);治疗后,两组D-D、TNF-α、IL-6、IL-8水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:阿奇霉素联合头孢哌酮舒巴坦治疗小儿细菌性肺炎的效果较好,可加速缓解症状,减轻炎性反应,促进康复。Objective:To analyze the effect of azithromycin combined with cefoperazone sulbactam in the treatment of pediatric bacterial pneumonia.Methods:A total of 66 children with bacterial pneumonia treated in Beijing Fengtai Hospital from February2017 to February 2023 were selected as the study subjects.They were divided into the observation group and the control group according to random number table method,with 33 cases in each group.Both groups received conventional treatment,the control group was treated with cefoperazone sulbactam on the basis of conventional treatment,and the observation group was treated with azithromycin on the basis of control group.The duration of symptoms and signs,duration of chest CT lesions,length of hospital stay,D-dimer(D-D) level and inflammatory factor level were compared between the two groups.Results:The duration of fever,wheezing,cough,lung rales,chest CT lesions and the length of hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.001).Before treatment,there was no significant difference in the levels of D-D,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin-8(IL-8) between the two groups(P>0.05);After treatment,the levels of D-D,TNF-α,IL-6 and IL-8 in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).Conclusion:Azithromycin combined with cefoperazone sulbactam in the treatment of pediatric bacterial pneumonia has good effects,and can relieve symptoms quickly,reduce inflammatory reactions and promote recovery.

关 键 词：儿童 细菌性肺炎 阿奇霉素 头孢哌酮舒巴坦 D-二聚体 

分 类 号：R725.6[医药卫生—儿科]