Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release  

作　　者：Qingye Meng Shuangling Zhong Jingfei Wang Zhenqian Zhang Yan Gao Xuejun Cui 

机构地区：[1]College of Chemistry Jilin University,Changchun,130012,China [2]College of Resources and Environment Jilin Agricultural University,Changchun,130118,China [3]State Key Laboratory of Supramolecular Structure and Materials,Jilin University,Changchun,130012,China [4]Weihai Institute for Bionics-Jlin University,Weihai,264400,China

出　　处：《Particuology》2024年第1期168-177,共10页颗粒学报（英文版）

基　　金：supported by the Pharmaceutical Health Industry Development Special Project of the Science and Technology Department of Jilin Province,China(grant No.20210401172YY);Interdisciplinary Research Funding Program for Doctoral Students of jilin University(grant No.101832020DjX026).

摘　　要：In this study,sodium alginate(SA),a non-toxic natural polysaccharide with good biocompatibility and biodegradability,was developed for targeted delivery of curcumin(CUR)in tumor therapy.The strategy is to sulfhydrylate the folic acid(FA)modified SA,and the CUR dissolved in ethyl acetate(EAC)phase is coated in microcapsules by a quick,efficient and environment-friendly sonochemical method.The EAC in the microcapsule core is volatile,which can be recycled and reused to reduce cost.The prepared mi-crocapsules(FA-RSMCs@CUR)exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro.FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro.It is expected to become a low-cost tumor targeting vector in the future,and has the potential to be promoted in clinical application.

关 键 词：Reductive-responsive Sodium alginate MICROCAPSULE Targeted delivery SONOCHEMICAL 

分 类 号：R318[医药卫生—生物医学工程] R730.5[医药卫生—基础医学]