抗性早熟汤剂治疗单纯性乳房早发育女童的效果  

Therapeutic Effects of Anti-precocious Decoction in Isolated Premature Thelarche

作　　者：杨利[1] 杨玉[1] 卢庆红[2] 石乔[1] 谢理玲[1] 徐庆博 黄强 YANG Li;YANG Yu;LU Qing-hong;SHI Qiao;XIE Li-ling;XU Qing-bo;HUANG Qiang(Department of Endocrinology,Genetics and Metabolism,Jiangxi Provincial Children’s Hospital,Nanchang 330000,China;Department of Pharmacy,Jiangxi Provincial Children’s Hospital,Nanchang 330000,China)

机构地区：[1]江西省儿童医院内分泌遗传代谢科,南昌330006 [2]江西省儿童医院药学部,南昌330006

出　　处：《实用临床医学（江西）》2024年第1期50-54,共5页Practical Clinical Medicine

基　　金：江西省中医药管理局科技计划(2019A048)。

摘　　要：目的探讨抗性早熟汤剂对单纯性乳房早发育(PT)女童的治疗效果。方法收集190例门诊就诊且病历信息相对完善的PT女童的临床资料,将予口服中药(基本组方为:淮山药、茯苓、知母、赤芍、生地黄、夏枯草等)及饮食生活指导的患儿归为治疗组(n=95),仅予饮食生活指导治疗的患儿归为对照组(n=95)。均在门诊随诊1年,比较2组临床结局,并对抗性早熟汤剂的安全性进行评价。结果干预后,治疗组的总有效率为94.74%,高于对照组的17.89%,中医证候疗效的总有效率为100.00%高于对照组的23.16%(P<0.05)。治疗组患儿的乳腺最大长径、卵巢容积、黄体生成素、卵泡刺激素、雌二醇及中医证候评分均较干预前明显降低(P<0.05),且小于对照组(P<0.05);随诊期间未见用药不良反应发生;治疗组PT女童转化为中枢性性早熟(CPP)的转化率低于对照组(8.42%比14.73%,P<0.05)。结论应用抗性早熟汤剂和饮食生活指导对PT女童进行干预,不仅可以改善女童的双侧乳腺长径、卵巢容积,还可以降低性激素水平及CPP的发生率,且安全性较高。Objective To investigate therapeutic effects of anti-precocious decoction in girls with isolated premature thelarche(IPT).Methods Clinical data of 190 girls with IPT who attended outpatient clinics and whose medical records were relatively complete were collected,and the children who were given anti-precocious decoction,an oral traditional Chinese medicine(formula:Chinese yam,Poria,Zhi Mu,Chi Pao,Radix Rehmanniae Praeparata,Xia Kucao,etc.),combined with dietary and life guidance,were categorized as the treatment group(n=95)and those who were given dietary and life guidance only were categorized as the control group(n=95).Both were followed up in the outpatient department for 1 year to compare the clinical outcomes of the 2 groups and to evaluate the safety of anti-precocious decoction.Results After the intervention,the total effective rate of the treatment group was 94.74%,and the effective rate of TCM syndrome efficacy was 100.00%,both significantly higher than those of the control group(17.89%and 23.16%,respectively,P<0.05).The maximum breast length diameter,ovarian volume,LH,FSH,E2,and TCM syndrome scores of the treatment group were significantly reduced compared to before intervention(P<0.05),and were smaller than those of the control group(P<0.05);no adverse drug reactions were observed during the follow-up period;the rate of conversion of PT to central precocious puberty(CPP)in the treatment group was lower than that of the control group(8.42%vs 14.73%,P<0.05).Conclusion Anti-precocious decoction combined with dietary and life guidance might help to improve bilateral breast length diamete and ovarian volume in girls,while also reducing the level of sex hormones and the probability of conversion to CPP,with relatively high safety.

关 键 词：单纯性乳房早发育 抗性早熟汤剂 饮食生活指导 疗效 女童 

分 类 号：R729[医药卫生—儿科]