基于数据挖掘的《证治准绳》治疗痹证用药规律  

Medication rules for treating arthralgia syndrome in Zhengzhi Zhunsheng based on data mining

作　　者：杰东 黄林丽 张莹[2] 吴斌[2] JIE Dong;HUANG Linli;ZHANG Ying;WU Bin(Graduate School,Hunan University of Chinese Medicine,Hunan,Changsha 410208,China;Department of Rheumatology,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China)

机构地区：[1]湖南中医药大学研究生院,湖南长沙410208 [2]重庆市中医院风湿病科,重庆400021

出　　处：《中国医药科学》2024年第3期112-115,共4页China Medicine And Pharmacy

基　　金：重庆市技术创新与应用发展专项重点项目(CSTB2022TIAD-KPX0187)。

摘　　要：目的 探讨《证治准绳》中治疗痹证的用药规律及王肯堂论治痹证的学术特色。方法 收集《证治准绳》痹、行痹、痛痹、着痹中所包含的内服中药方,运用Microsoft Excel 2010建立数据库,并规范中药处方,应用SPSS Modeler 18.0进行关联规则分析,运用SPSS Statistics 25.0对高频药物进行聚类分析。结果 共纳入中药复方112首,涉及中药194味,高频药物包括当归、防风、炙甘草、生甘草、羌活等,功效分类以补虚药、解表药、活血化瘀药为主,药性以温性、平性、寒性为主,药味以辛、苦、甘为主,归经以脾、肝、肺、肾四经为主,治疗痹证的主要药对包括苍术-黄柏、防风-独活、升麻-柴胡等,通过聚类分析得出7个核心药组,C1:柴胡、升麻、黄芪;C2:苍术、黄柏、陈皮、白芍、生甘草;C3:白术、人参;C4:茯苓、炙甘草、半夏;C5:防风、羌活;C6:川芎、当归、肉桂、麻黄;C7:黄芩。结论 王肯堂治疗痹证注重温补脾肾,善用风药,同时佐以清热祛湿、活血化瘀、调和营卫之法,体现了王肯堂在痹证辨治中强调因虚致痹,重视扶正祛邪的学术特点。Objective To explore the medication rules for treating arthralgia syndrome in Zhengzhi Zhunsheng and the academic characteristics of Wang Kentang's theory on treating arthralgia syndrome.Methods The oral Chinese traditional medicine prescriptions included in the Zhengzhi Zhunsheng for arthralgia,migratory arthralgia,pain arthralgia,and damp arthralgia were collected.Microsoft Excel 2010 was used to establish a database and standardize traditional Chinese medicine prescriptions.SPSS Modeler 18.0 was used for association rules,and SPSS Statistics 25.0 was used for cluster analysis of high-frequency drugs.Results A total of 112 traditional Chinese medicine prescriptions were included,involving 194 traditional Chinese medicine ingredients.High-frequency drugs included Angelica sinensis,Saposhnicovia divaricata,Radix glycyrrhizae preparata,Radix glycyrrhizae,and Notopterygium root.The efficacy classification was mainly focused on deficiency-tonifying drugs,exterior syndrome-relieving drugs,and blood-activating and stasiseliminating drugs.The drug properties were mainly warm,mild,and cold.The drug flavors were mainly pungent,bitter,and sweet.The meridians were mainly focused on the four meridians of the spleen,liver,lung,and kidney.The main drug pairs for treating arthralgia syndrome included Atractylodes rhizome-Phellodendron amurense,Saposhnicovia divaricata-Radix angelicae pubescentis,Cimicifuga-Radix bupleuri,etc.Through cluster analysis,7 core drug groups were identified,including C1:Radix bupleuri,Cimicifuga,and Radix astragali;C2:Atractylodes rhizome,Phellodendron amurense,tangerine peel,radix paeoniae alba,and Radix glycyrrhizae;C3:Atractylodes macrocephala,Ginseng;C4:Poria cocos,Radix glycyrrhizae preparata,Pinellia ternata;C5:Saposhnicovia divaricata,Notopterygium root;C6:Ligusticum wallichii,Angelica sinensis,Cinnamon,Ephedra;C7:Scutellaria baicalensis.Conclusion Wang Kentang's treatment of arthralgia syndrome focuses on warming and tonifying the spleen and kidney,making good use of wind-dispelling medicine,

关 键 词：证治准绳 数据挖掘 痹证 用药规律 

分 类 号：R255.6[医药卫生—中医内科学]