CMTM5基因对心肌梗死后血管再生的研究  

The study of the CMTM5 gene on angiogenesis after myocardial infarction

作　　者：赵嘉昊 刘长梅[2] 商雪 祝慧 李昕玺 徐会圃[1] ZHAO Jiahao;LIU Changmei;SHANG Xue;ZHU Hui;LI Xinxi;XU Huipu(Department of Cardiovasology,Binzhou Medical University Hospital,Shandong,Binzhou 256600,China;Department of Endocrinology,Binzhou Medical University Hospital,Shandong,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院心血管内科,山东滨州256600 [2]滨州医学院附属医院内分泌科,山东滨州256600

出　　处：《中国医药科学》2024年第4期47-50,共4页China Medicine And Pharmacy

基　　金：山东省自然科学基金(2014ZRB14275)。

摘　　要：心肌梗死(MI)是由于心肌缺血、坏死、分解而造成的心肌损害,是冠状动脉疾病发展的终末阶段。随着人民生活水平的提高,我国心血管疾病患病率不断增加,心血管疾病已成为严重危害人类健康的主要疾病。MI后血管再生是近年来心血管领域的研究热点。趋化素样因子超家族成员5(CMTM5)调节多种机体反应,在包括血管再生、炎症、肿瘤的侵袭、分化、抗细胞凋亡中发挥重要作用。因此,CMTM5在MI后心血管修复过程中扮演着至关重要的角色。本文重点综述CMTM5及其介导的信号通路在急性MI损伤区心肌组织血管再生的作用机制,并对相关问题进行讨论,以求为临床实践和基础研究提供一定的理论依据。Myocardial infarction(MI)is a kind of myocardial damage caused by myocardial ischemia,necrosis,and decomposition,which is the end stage of coronary artery disease.With the improvement of people’s living standards,the prevalence of cardiovascular diseases in China is increasing,and cardiovascular diseases have become a major disease that seriously endangers human health.Angiogenesis after myocardial infarction has been a study hotspot in the cardiovascular field in recent years.Chemokine-like factor superfamily5(CMTM5)regulates various body reactions,including playing important roles in angiogenesis,inflammation,tumor invasion,differentiation,and anti-apoptosis.Therefore,CMTM5 plays a crucial role in the cardiovascular repair process after MI.This article focuses on the mechanism of action of CMTM5 and CMTM5-mediated signaling pathways in myocardial tissue angiogenesis in acute myocardial infarction injury areas and discusses related issues to provide a theoretical basis for clinical practice and basic study.

关 键 词：趋化素样因子超家族成员5 心肌梗死 血管再生 细胞凋亡 

分 类 号：R542.22[医药卫生—心血管疾病]