(E)-2-[(E)-亚苄基]庚醛肟的合成与表征  

Synthesis and characterization of(E)-2-[(E)-benzylidene]heptanal oxime

作　　者：王恰如 王艳娇[1] 朱周静 唐文强 WANG Qia-ru;WANG Yan-jiao;ZHU Zhou-jing;TANG Wen-qiang(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xianyang 712046,China;Xianyang Key Laboratory of Molecular Imaging and Drug Synthesis,Xianyang 712046,China)

机构地区：[1]陕西国际商贸学院医药学院,陕西咸阳712046 [2]咸阳市分子影像与药物合成重点实验室,陕西咸阳712046

出　　处：《化学工程师》2024年第2期1-4,共4页Chemical Engineer

基　　金：2023年陕西省大学生创新创业训练计划项目(S202313123046);陕西国际商贸学院“中药药效物质研究”创新团队资助项目(SSY18TD01);咸阳市分子影像与药物合成重点实验室项目(2021QXNL-PT-0008)。

摘　　要：本文报道(E)-2-[(E)-亚苄基]庚醛肟(3)的合成及表征。在Na OH碱性条件下,α-戊基肉桂醛(1)与盐酸羟胺(2)发生缩合反应得到目标产物。考察反应条件发现,当物料比为n_((化合物2))∶n_((化合物1))=1.4∶1,该反应在甲醇中于50℃条件下反应20min,产物收率达到70.5%。产物结构经过1H NMR、13C NMR、ESI-MS及XRD单晶衍射表征。该合成方法具有工艺简单、反应时间短、产物收率高等优点。The synthesis and characterization of(E)-2-[(E)-benzylidene]heptanal oxime(3)was reported.The target compound was synthesized by condensation reaction ofα-amyl cinnamaldehyde(1)with hydroxylamm-onium chloride(2)under sodium hydroxide alkaline condition.It was found that the yield was 70.5%when the mole ratio of compound(2)to compound(1)was 1.4∶1 and the reaction was carried out in methanol at 50℃for 20min.The structure of the product was characterized by 1H NMR,13C NMR,ESI-MS and XRD single crystal diffraction.The synthesis method has the advantages of simple process,short reaction time and high yield.

关 键 词：肟类化合物 合成 表征 单晶衍射 

分 类 号：TQ463[化学工程—制药化工]