Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes  

作　　者：Hui Yang Dinshaw J.Patel 

机构地区：[1]Key Laboratory of RNA Science and Engineering,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai,China [2]Structural Biology Program,Memorial Sloan-Kettering Cancer Center,New York,NY,USA

出　　处：《Cell Research》2024年第2期99-100,共2页细胞研究（英文版）

摘　　要：RNA-guided DNA endonucleases are broadly associated with and play critical roles in prokaryotic adaptive immunity-based CRISPR-Cas systems and IS200/605 family transposons.The Feng Zhang lab recently elucidated the phylogeny,enzymatic activity and DNA recognition mechanism of its eukaryotic counterpart Fanzor,while further reprogramming Fanzor for human genome editing applications,thereby highlighting a universal RNA-guided DNA cleavage mechanism spanning from prokaryotes to eukaryotes.

关 键 词：PHYLOGENY mechanism thereby 

分 类 号：Q78[生物学—分子生物学]