AA-CYP-HETE/EETs代谢通路与心血管疾病治疗药物研究现状的分析  

Analysis of the research status of AA-CYP-HETE/EETs metabolic pathways and cardiovascular disease therapeutic drugs

作　　者：胡明霞 何永芸 姚玥 莫晓丹 杨秀芬 HU Ming-xia;HE Yong-yun;YAO Yue;MO Xiao-dan;YANG Xiu-fen(School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China;Key Laboratory of Guangxi Zhuang and Yao Medicine,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China;Key Laboratory of Traditional Chinese Medicine Neuro-Metabolism and Immunopharmacology of Guangxi Education Department,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学药学院,广西壮族自治区南宁530200 [2]广西中医药大学,广西壮瑶药重点实验室,广西壮族自治区南宁530200 [3]广西中医药大学,广西高校中药神经-代谢及免疫药理重点实验室,广西壮族自治区南宁530200

出　　处：《中国临床药理学杂志》2024年第4期619-623,共5页The Chinese Journal of Clinical Pharmacology

基　　金：广西自然科学基金资助项目(2015GXNSFDA139023,2020GXNSFAA297165);广西壮瑶药重点实验室建设项目计划基金资助项目(GXZYZZ2020-08,GXZYZZ2022-08);广西中医药大学广西一流学科(中药学)建设开放课题基金资助项目(2019XK122)。

摘　　要：20-羟基二十碳四烯酸(20-HETE)及环氧二十碳三烯酸(EETs)是花生四烯酸(AA)经细胞色素P450(CYP)酶系代谢的产物。20-HETE主要由CYP4A、CYP4F将AA代谢产生,对心脑血管系统有一定的毒性作用。EETs主要由CYP2J、CYP2C将AA代谢产生,对心脑血管系统有一定的保护作用。本文通过查阅文献综述AA-CYP-HETE/EETs代谢通路相关药物对心肌肥厚、高血压、心力衰竭、心肌梗死等心血管疾病的作用及作用机制,以期为心血管疾病的临床用药提供参考,为心血管疾病治疗药物的研究和开发提供思路与方向。20-hydroxyeicosatetraenoic acid(20-HETE) and epoxyeicosatrienoic acids(EETs) are products of enzyme metabolism of arachidonic acid(AA) by cytochrome P450(CYP).20-HETE is mainly produced by CYP4A,CYP4F metabolism of AA,which has a certain toxic effect on the cardiovascular and cerebrovascular system.EETS is mainly produced by CYP2J,CYP2C metabolizes AA,which has a certain protective effect on the cardiovascular and cerebrovascular system.This article reviews the effects and mechanisms of drugs related to AA-CYP-HETE/EETs metabolic pathway on cardiovascular diseases such as myocardial hypertrophy,hypertension,heart failure,and myocardial infarction,in order to provide a reference for the clinical use of cardiovascular diseases and provide ideas and directions for the basic research and development of cardiovascular disease treatment drugs.

关 键 词：花生四烯酸 细胞色素P450 20-羟基二十碳四烯酸 环氧二十碳三烯酸 心血管疾病 

分 类 号：R972[医药卫生—药品]