EBV感染对川崎病患儿冠状动脉病变及TIMP-1和NF-κB与IκBα的影响  

Effects of EBV infection on coronary artery disease and TIMP-1,NF-κB and IκBa in children with Kawasaki disease

作　　者：梁鹏 娄莹 崔怀亮 张玉 杨成胜 LIANG Peng;LOU Ying;CUI Huai-liang;ZHANG Yu;YANG Cheng-sheng(Xinxiang Central Hospital,The Fourth Clinical College of Xinxiang Medical College,Xinxiang,Henan 453000,China)

机构地区：[1]新乡市中心医院新乡医学院第四临床学院儿科二病区,河南新乡453000

出　　处：《中华医院感染学杂志》2024年第4期589-593,共5页Chinese Journal of Nosocomiology

基　　金：河南省医学科技攻关计划省部共建青年基金资助项目(SB201904015)。

摘　　要：目的研究Epstein-Barr病毒(EBV)对川崎病患儿冠状动脉病变及基质金属蛋白酶抑制剂-1(TIMP-1)、核因子-κB(NF-κB)、核因子-κB抑制蛋白(IκBα)的影响.方法以2019年6月—2022年12月新乡市中心医院收治的136例川崎病患儿作为研究对象,根据患儿是否发生EB病毒感染及感染情况将其分为无EB病毒感染的对照组(70例)、既往发生EB病毒感染的既往感染组(30例)及目前发生EB病毒感染的急性感染组(36例),统计三组临床资料,比较三组冠状动脉病变及血清TIMP-1、NF-κB、IKBα蛋白表达和炎症指标.结果急性感染组、既往感染组及对照组冠状动脉损伤(CAL)占比呈降低趋势(P<0.05);急性感染组左回旋支(LCX)病变患儿占比高于既往感染组及对照组(P<0.05);急性感染组、既往感染组及对照组血清TIMP-1、IκBα蛋白表达水平呈升高趋势(P<0.05),血清NF-κB蛋白表达水平及血清C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-iβ)、IL-6、IL-8呈降低趋势(P<0.05).结论EB病毒感染可加重川崎病患儿冠状动脉病变与患儿机体炎症反应,对血清TIMP-1、NF-κB、IκBα蛋白表达水平及感染指标水平产生影响.OBJECTIVE To investigate the effects of Epstein Barr virus(EBV)infection on coronary artery disease,and matrix metalloproteinase inhibitor-1(TIMP-1),nuclear factor-κB(NF-κB),and nuclear factor-κB inhibitory protein(IκBα)in children with Kawasaki disease.METHODS A total of 136 children with Kawasaki disease ad-mitted to Xinxiang Central Hospital from Jun.2019 to Dec.2022 were selected as the study subjects,and they were divided into the control group without EB virus infection(70 cases),the previously infected group with pre-vious EB virus infection(30 cases),and the acutely infected group currently infected with EB virus infection(36 cases)according to whether they had EB virus infection and the status of their infection.The clinical data of the three groups were collected,and the coronary artery disease,as well as the expression of serum TIMP-1,NF-κB,and IκBαprotein,and the index of inflammation were compared among the three groups.RESULTS The propor-tion of coronary artery injury(CAL)in the acutely infected group,the previously infected group,and the control group showed a decreasing trend(P<0.05).The proportion of children with left circumflex artery(LCX)lesions in the acutely infected group was higher than that in the previously infected group and control group(P<0.05).The expression levels of serum TIMP-1 and IκBαprotein showed a trend of increase in the acutely infected group,the previously infected group and the control group(P<0.05),while the expression level of serum NF-κB protein and serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6 and IL-8 showed a trend of decrease(P<0.05).CONCLUSION Epstein-barr virus infection aggravated coronary artery dis-ease and inflammatory response in children with Kawasaki disease,which had an impact on the expression level of serum TIMP-1,NF-κB,IκBα protein and the level of infection indicators.

关 键 词：EPSTEIN-BARR病毒 川崎病 临床特征 冠状动脉病变 基质金属蛋白酶抑制剂-1 核因子-κB 核因子-κB抑制蛋白 

分 类 号：R543[医药卫生—心血管疾病]