基于数据挖掘分析中成药治疗肺炎的用药规律  

Analysis of Pharmaceutical Rules of Traditional Chinese Medicine in the Treatment of Pneumonia Based on Data Mining

作　　者：刘新颖 杨硕[1] 王皓楷 李焕敏 李新民[1] Liu Xin-ying;Yang Shuo;Wang Hao-kai;Li Huan-min;Li Xin-min(The First Affiliated Hospital of Tianjin University of Chinese Medicine,Tianjin 300000)

机构地区：[1]天津中医药大学第一附属医院、国家针灸中医临床医学研究中心,天津300000

出　　处：《世界中西医结合杂志》2024年第2期248-254,共7页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(82104931)。

摘　　要：目的 探究中成药治疗肺炎的用药规律及组方特点。方法 收集并筛选《中国药典》《中国临床药物大辞典·中药成方制剂》《国家中成药标准汇编》以及《新编国家中成药》中记录的主要治疗肺炎的中成药处方。聚类分析处方组方用药规律、药物的使用频次、性味归经及功效。结果 共纳入118个中成药处方,包括了16种不同的中医证候,其中最常见的证型为痰热壅肺证。涉及220种中药,主要根据其功效分为清热、化痰止咳、平喘、补虚等不同类别。药性中,寒性最为常见,其次是温性和平性;药味以苦味和辛味为主,主要归属于肺经,其次是胃、脾和肝经。通过关联规则分析,得出了25组核心药物的组合。通过系统聚类分析,归类为8个不同的类别。结论 肺炎的核心中医证候主要为痰热闭肺证,其病机基础涉及痰、瘀、热和毒,病理基础在于肺气郁闭。因此,在治疗中,强调宣肺气、消痰瘀、清热毒、润肺阴等功效的综合运用。Objective To explore the rules and characteristics of traditional Chinese medicine(TCM)in the treatment of pneumonia.Methods Prescriptions of TCM for pneumonia were collected and selected from the Chinese Pharmacopoeia,Chinese Clinical Pharmacopoeia:Traditional Chinese Medicine Prescriptions,National Standard of Traditional Chinese Medicine,and New Compilation of National Chinese Patent Medicines.Cluster analysis was conducted on the prescription formulae to identify patterns in the use of medicines,frequency of use,properties and tastes,meridian affiliations,and therapeutic effects.Results A total of 118 TCM prescriptions were included,involving 16 different TCM syndromes,with the most common syndrome being phlegm-heat obstructing lung.There were 220 kinds of Chinese medicine involved,which were mainly divided into categories such as clearing heat,resolving phlegm and relieving cough,relieving asthma and tonifying deficiency.Regarding the nature of the herbs,cold property was the most common,followed by warm and neutral properties.The tastes of medicine were primarily bitter and acrid,mainly belonging to the lung meridian,followed by the stomach,spleen and liver meridians.The association rule analysis unveiled 25 core herbal combinations.Finally,these prescriptions were classified into 8 different categories by systematic clustering analysis.Conclusion The core TCM syndrome of pneumonia is phlegm-heat obstructing lung,and its pathogenesis involves phlegm,stasis,heat,and toxins,with the pathological basis being the stagnation of lung qi.Therefore,in treatment,it is emphasized to comprehensively apply the medicine effects of ventilating lung qi,dispelling phlegm and stasis,clearing heat and toxins,and nourishing lung yin.

关 键 词：中成药 肺炎 数据挖掘 R语言 关联分析 聚类分析 用药规律 

分 类 号：R563.1[医药卫生—呼吸系统]