火针温通法联合复方卡力孜然酊治疗白癜风稳定期患者的疗效观察  

Clinical Observation of Fire-Needle Warming and Dredging Combined with Compound Kaliziran Tincture in the Treatment of Vitiligo in the Stable Phase

作　　者：孟威威 夏欢欢[1] 李庆娟[1] MENG Wei-wei;XIA Huan-huan;LI Qing-juan(Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou Henan 450003)

机构地区：[1]河南省中医院,河南郑州450003

出　　处：《世界中西医结合杂志》2024年第2期336-340,346,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：河南省中医药科学研究专项课题(2021JDZX2104)。

摘　　要：目的 探讨应用火针温通法联合复方卡力孜然酊治疗白癜风稳定期患者的临床疗效。方法 选取2020年8月—2021年8月期间河南省中医院门诊收治的白癜风稳定期患者90例,按随机数字表法分为光疗组和中医组,每组各45例。光疗组使用308 nm准分子激光,中医组使用火针温通法联合复方卡力孜然酊治疗,1个月为1个疗程,均治疗3个疗程。治疗3个疗程结束后,观察比较两组患者临床疗效、第一次光疗/火针治疗24 h后不良反应情况,治疗前后皮损恢复情况、血清炎症及免疫指标[白细胞介素-1β(Interleukin-1β,IL-1β)和核转录因子-κB(Nuclear Factor-κB,NK-κB)、免疫球蛋白A(Immunoglobulin A,IgA)和免疫球蛋白G(Immunoglobulin G,IgG)]、生活质量评分(Dermatology life quality index, DLQI)。结果 治疗后中医组临床疗效总有效率95.00%(38/40)与光疗组临床疗效总有效率88.37%(38/43)比较,差异无统计学意义(P>0.05)。治疗后两组患者皮损面积均较治疗前缩小,差异有统计学意义(P<0.05);且中医组皮损面积明显小于光疗组,差异有统计学意义(P<0.05)。治疗后中医组靶部位色素恢复程度优于光疗组,差异有统计学意义(P<0.05)。治疗后两组患者血清炎症IL-1β、NK-κB水平和免疫因子IgA、IgG水平均较治疗前降低,差异有统计学意义(P<0.05);且中医组血清炎症IL-1β、NK-κB水平和免疫因子IgA、IgG水平均明显低于光疗组,差异有统计学意义(P<0.05)。治疗后两组患者生活质量(DLQI)评分均较治疗前降低,差异有统计学意义(P<0.05);两组患者生活质量(DLQI)评分组间比较,差异无统计学意义(P>0.05)。第一次光疗/火针治疗24 h后,光疗组皮肤不良反应发生率13.95%(6/43)与中医组15.00%(6/40)比较,差异无统计学意义(P>0.05)。结论 白癜风稳定期应用火针温通法合复方卡力孜然酊治疗的临床疗效理想,可显著促进患者的皮损恢复、调节血清炎症及免疫因子水平,�Objective To evaluate the clinical efficacy of fire-needle warming and dredging combined with compound Kaliziran Tincture in the treatment of patients with vitiligo in the stable phase.Methods Between August 2020 and August 2021,90 patients with vitiligo in the stable phase from the Outpatient Department of Henan Provincial Hospital of Traditional Chinese Medicine were selected and divided into a phototherapy group and a traditional Chinese medicine(TCM)group by a random number table,with 45 in each group.The phototherapy group was treated with 308 nm excimer laser,while the TCM group underwent fire-needle warming and dredging combined with compound Kaliziran Tincture.The treatment lasted for three courses,each course for one month.Clinical efficacy,adverse reactions within 24 hours after the initial phototherapy/fire needling,changes in lesion recovery,serum inflammatory and immune markers[Interleukin-1β(IL-1β),Nuclear Factor-kappa B(NF-κB),Immunoglobulin A(IgA),and Immunoglobulin G(IgG)],and Dermatology Life Quality Index(DLQI)scores were compared between the two groups before and after treatment.Results The total effective rate of the TCM group(95.00%,38/40)was not significantly different from that of the phototherapy group(88.37%,38/43)(P>0.05).Both groups presented a reduction in lesion area and an improvement in serum inflammation and immune markers after treatment(P<0.05),with the TCM group exhibiting greater reductions and improvements(P<0.05).The degree of pigment recovery at the target site was better in the TCM group than the phototherapy group(P<0.05).DLQI scores were reduced in both groups post-treatment(P<0.05),while no obvious difference was observed between the two groups(P>0.05).There were no significant differences in the incidence of adverse skin reactions between the phototherapy group and TCM group(13.95%,6/43 vs.13.95%,6/43)(P>0.05).Conclusion Fire-needle warming and dredging combined with compound Kaliziran Tincture in the treatment of vitiligo in the stable phase showed promise in clini

关 键 词：白癜风 稳定期 308 nm准分子激光 火针 温通法 复方卡力孜然酊 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]