通脉化瘀胶囊治疗椎动脉型颈椎病患者的疗效及对其椎基底动脉超声参数的影响  

Efficacy of Tongmai Huayu Capsule in the Treatment of Patients with Vertebral Artery Type-Cervical Spondylosis and Its Impact on Ultrasound Parameters of Vertebral Basilar Artery

作　　者：辛永健 王印岭 张晓红 谢云港 XIN Yong-jian;WANG Yin-ling;ZHANG Xiao-hong;XIE Yun-gang(Hengshui Hospital of Traditional Chinese Medicine,Hengshui Hebei 053000)

机构地区：[1]衡水市中医医院,河北衡水053000

出　　处：《世界中西医结合杂志》2024年第2期369-373,378,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局2022年度中医药类科研计划(2022624)。

摘　　要：目的 探究通脉化瘀胶囊治疗椎动脉型颈椎病患者的疗效及对其椎基底动脉超声参数的影响。方法 选取2021年5月—2022年12月期间衡水市中医医院收治的椎动脉型颈椎病患者114例,按简单随机数字表法分为对照组和研究组,每组各57例。对照组在常规干预基础上给予盐酸氟桂利嗪胶囊,研究组在对照组基础上采取通脉化瘀胶囊。治疗4周后,观察比较两组患者临床疗效及治疗前后椎基底动脉超声参数[椎-基底动脉平均血流速度(Vertebrobasilar mean blood flow velocity, Vm)、收缩期峰值血流速度(Peak systolic blood flow velocity, Vs)、舒张期末血流速度(End-diastolic blood flow velocity, Vd)、搏动指数(Pulsation index, PI)、阻力指数(Resistance index, RI)]、中医证候积分、眩晕症状相关评分、颈椎关节活动度(颈部左旋、右旋、左侧屈、右侧屈、前屈、后伸)。结果 治疗后两组患者椎-基底动脉Vm、Vs、Vd超声参数均较治疗前升高,RI、PI超声参数均较治疗前降低,差异有统计学意义(P<0.05);且研究组椎-基底动脉Vm、Vs、Vd超声参数均明显高于对照组,RI、PI超声参数均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者中医证候头晕目眩、耳聋耳鸣、颈肩处疼痛及急躁易怒、入睡困难、手指麻木、记忆力下降积分均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候头晕目眩、耳聋耳鸣、颈肩处疼痛及急躁易怒、入睡困难、手指麻木、记忆力下降积分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者眩晕症状肩颈痛、眩晕、头痛、日常生活及工作、心理及社会适应评分均较治疗前降低,差异有统计学意义(P<0.05);且研究组眩晕症状肩颈痛、眩晕、头痛、日常生活及工作、心理及社会适应评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者颈椎关节活动度颈部�Objective To evaluate the therapeutic effect of Tongmai Huayu Capsule on patients with vertebral artery type-cervical spondylosis and its impact on the ultrasonic parameters of the vertebral-basilar artery.Methods A total of 114 patients with vertebral artery type-cervical spondylosis treated at the Hengshui Hospital of Traditional Chinese Medicine from May 2021 to December 2022 were selected and randomly divided into a control group and a study group by a random number table method,with 57 in each group.The control group received flunarizine hydrochloride capsules along with routine interventions,while the study group was treated with Tongmai Huayu Capsule on the basis of the control group.Before and after the 4-week treatment,ultrasonic parameters of the vertebral basilar artery[average blood flow velocity(Vm),peak systolic velocity(Vs),end-diastolic velocity(Vd),pulsation index(PI),and resistance index(RI)],traditional Chinese medicine(TCM)syndrome scores,vertigo symptom-related scores,and cervical joint mobility(left rotation,right rotation,left lateral flexion,right lateral flexion,forward flexion,and backward extension)were assessed.Results After treatment,Vm,Vs,and Vd of the vertebral basilar artery increased,while RI and PI decreased in both groups(P<0.05).The study group had higher Vm,Vs,and Vd as well as lower RI and PI than the control group(P<0.05).TCM syndrome scores for dizziness,deafness,tinnitus,neck and shoulder pain,irritability,difficulty in falling asleep,finger numbness,and memory decline decreased after treatment in both groups(P<0.05),with the study group showing more significant improvements compared wtih the control group(P<0.05).Additionally,scores for shoulder and neck pain,dizziness,headache,daily life and work,and psychological and social adaptation were lowered in both groups,with the study group exhibiting greater improvements than the control group(P<0.05).Both groups had increased cervical joint mobility after treatment,and the study group showed a greater increase than the contro

关 键 词：通脉化瘀胶囊 椎动脉型颈椎病 椎基底动脉 超声参数 

分 类 号：R681.55[医药卫生—骨科学]