丙硫菌唑原药中3个主要杂质合成及产生历程分析  

Synthesis of three main impurities of prothioconazole and analysis of their generation procedure

作　　者：杨丙连 王建博 丁亚伟 YANG Binglian;WANG Jianbo;DING Yawei(CAC Nantong Chemical Co.,Ltd.,Nantong 226407,Jiangsu,China;CAC Shanghai Chemical Co.,Ltd.,Shanghai 201612,China)

机构地区：[1]南通泰禾化工股份有限公司,江苏南通226407 [2]上海泰禾化工有限公司,上海201612

出　　处：《世界农药》2024年第2期47-51,60,共6页World Pesticide

摘　　要：为获得丙硫菌唑原药中脱氯丙硫、脱硫丙硫和甲基化丙硫3个主要杂质,分别以氯化苄、丙硫菌唑原药为起始原料,设计合成路线并对3个杂质进行了合成,杂质含量>97%,其结构经LC-MS和1H NMR等结构表征确证。基于丙硫菌唑原药合成路线和相关文献资料调查,分析推测了3个杂质产生的可能历程。研究结果可为丙硫菌唑研究、工艺开发提供基础与指导。In order to obtain the three main impurities of dechloroprothioconazole,dethioprothioconazole,and methylprothioconazole in prothioconazole TC,benzyl chloride,prothioconazole were used as starting materials.A synthesis route was designed and the three impurities were synthesized.The impurity content was>97%,and their structure was confirmed by LC-MS and 1H NMR structural characterization.Based on the synthesis route of prothioconazole TC and relevant literature investigation,the possible processes of three impurities were analyzed and speculated.The results can provide a foundation and guidance for the research and process development of prothioconazole.

关 键 词：丙硫菌唑 杂质 脱氯丙硫菌唑 脱硫丙硫菌唑 甲基化丙硫菌唑 合成 

分 类 号：TQ450[化学工程—农药化工]