硝酸银溶液协同改性中心静脉导管覆涂材料的应用性能测试  

Application performance test of silver nitrate solution synergistically modified central venous catheter coating material

作　　者：王志军 孙玲玲 栾旭辉 陈珊珊[1] 张娜[1] 孙圣 WANG Zhijun;SUN Lingling;LUAN Xuhui;CHEN Shanshan;Zhang Na;SUN Sheng(Beijing Rehabilitation Hospital affiliated to Capital Medical University,Beijing 100144,China;Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京康复医院,北京100144 [2]首都医科大学,北京100069

出　　处：《粘接》2024年第3期82-85,共4页Adhesion

基　　金：北京市科技攻关项目(项目编号:BJXD2022GJ573)。

摘　　要：针对传统中心静脉导管材料抗菌性能和生物相容性较差的问题,提出一种新型医用载银中心静脉导管改性,并对其综合性能进行研究。结果表明,在聚多巴胺中心静脉导管表面的纳米银颗粒成功负载。硝酸银浓度为0.01 mol/L制备的载银中心静脉导管材料(0.01 Ag-DH/CVC)在较低载银含量的条件下表现出良好的抑菌性能和生物相容性,不会对细胞活性和细胞的形态产生影响。制备的载银中心静脉导管用于临床护理应用,在穿刺成功率和并发症发生率方面均明显优于传统PICC导管,表现出良好的医用性能。In order to solve the problem of poor antibacterial performance and biocompatibility of traditional central venous catheter materials,a new type of medical silver-loaded central venous catheter modification was proposed,and its comprehensive performance was studied.The results showed that silver nanoparticles were successfully loaded onto the surface of the polydopamine central venous catheter.The silver loaded central venous catheter material(0.01Ag-DH/CVC)prepared with a silver nitrate concentration of 0.01 mol/L exhibited good antibacterial performance and biocompatibility under low silver content conditions,without affecting cell activity and morphology.The prepared silver loaded central venous catheter used for clinical nursing applications was significantly superior to traditional PICC catheters in terms of puncture success rate and complication incidence,demonstrating good medical performance.

关 键 词：中心静脉导管 抗菌性能 载银涂层 聚多巴胺 医用性能 

分 类 号：R318.08[医药卫生—生物医学工程] TQ460.34[医药卫生—基础医学]