Isogeometric Analysis of Hyperelastic Material Characteristics for Calcified Aortic Valve  

作　　者：Long Chen Ting Li Liang Liu Wenshuo Wang Xiaoxiao Du Wei Wang 

机构地区：[1]School of Mechanical Engineering,University of Shanghai for Science and Technology,Shanghai,200093,China [2]Department of Cardiac Surgery,Zhongshan Hospital,Fudan University,Shanghai,200093,China [3]School of Mechanical Engineering and Automation,Beihang University,Beijing,100191,China

出　　处：《Computer Modeling in Engineering & Sciences》2024年第6期2773-2806,共34页工程与科学中的计算机建模（英文）

基　　金：supported by the Natural Science Foundation of China(Project Nos.52075340 and 61972011);the Shanghai Special Research Project on Aging Population and Maternal and Child Health(Project No.2020YJZX0106).

摘　　要：This study explores the implementation of computed tomography(CT)reconstruction and simulation techniques for patient-specific valves,aiming to dissect the mechanical attributes of calcified valves within transcatheter heart valve replacement(TAVR)procedures.In order to facilitate this exploration,it derives pertinent formulas for 3D multi-material isogeometric hyperelastic analysis based on Hounsfield unit(HU)values,thereby unlocking foundational capabilities for isogeometric analysis in calcified aortic valves.A series of uniaxial and biaxial tensile tests is executed to obtain an accurate constitutive model for calcified active valves.To mitigate discretization errors,methodologies for reconstructing volumetric parametric models,integrating both geometric and material attributes,are introduced.Applying these analytical formulas,constitutive models,and precise analytical models to isogeometric analyses of calcified valves,the research ascertains their close alignment with experimental results through the close fit in displacement-stress curves,compellingly validating the accuracy and reliability of the method.This study presents a step-by-step approach to analyzing themechanical characteristics of patient-specific valves obtained fromCT images,holding significant clinical implications and assisting in the selection of treatment strategies and surgical intervention approaches in TAVR procedures.

关 键 词：Calcified aortic valves tensile test constitutive relations CT reconstruction isogeometric hyperelastic analysis 

分 类 号：R318.08[医药卫生—生物医学工程] TP3[医药卫生—基础医学]