巨细胞病毒活动性感染患儿NK细胞及GGT水平与HCMV DNA的相关性  

Associations of NK cell and GGT levels with HCMV DNA in pediatric cytomegalovirus active infections

作　　者：张瑜 郭轲 刘道路 ZHANG Yu;GUO Ke;LIU Dao-Lu(Department of Pediatrics,Suixi Hospital,Anhui 235000,China)

机构地区：[1]濉溪县医院儿二科,安徽235000

出　　处：《肝脏》2024年第2期220-222,共3页Chinese Hepatology

基　　金：淮北市科技计划项目(rj201805)。

摘　　要：目的探讨巨细胞病毒(HCMV)活动性感染患儿自然杀伤(NK)细胞及γ-谷氨酰转肽酶(GGT)水平与HCMV DNA的相关性。方法选取2021年6月—2022年6月濉溪县医院收治的150例HCMV活动性感染患儿纳入研究对象,根据HCMV DNA水平将患儿分为低载量组(n=52)、中载量组(n=64)、高载量组(n=34),另外选取我院同期50名健康婴儿作为对照组。比较4组的肝功能指标[天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、总胆汁酸(TBA)、GGT]及NK细胞水平,分析肝功能指标及NK细胞与HCMV DNA的相关性。结果4组AST、ALT、ALP、TBA比较无明显差异(P>0.05),4组GGT分别为(10.28±2.69)U/L、(15.64±3.13)U/L、(18.56±3.22)U/L、(23.77±4.17)U/L,4组NK细胞分别为(4.87±1.04)%、(6.14±1.15)%、(13.55±2.33)%、(19.84±3.27)%,GGT、NK随HCMV DNA载量升高而上升(P<0.05);经相关性分析,AST、ALT、ALP、TBA与HCMV DNA无明显相关性(P>0.05),NK细胞、GGT与HCMV DNA呈现正相关(P<0.05)。结论NK细胞及GGT水平与HCMV DNA具有相关性,检测HCMV DNA有助于HCMV活动性感染的诊断,但无法评估病情严重程度。Objective To explore the associations between natural killer(NK)cell counts,γ-glutamyl aminotransferase(GGT)levels,and human cytomegalovirus(HCMV)DNA in pediatric patients with active HCMV infection.Methods In this study,150 pediatric patients with active HCMV infection were examined,who were admitted to our hospital from June 2021 to June 2022.Based on their HCMV DNA levels,these patients were stratified into three groups:a low load group(n=52),a medium load group(n=64),and a high load group(n=34).Additionally,a control group of 50 healthy infants was included.Liver function indices-specifically aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(ALP),total bile acids(TBA),GGT——along with NK cell levels were compared across the four groups.The correlation between liver function,NK cell levels,and HCMV DNA load was also analyzed in the study.Results In the study,no significant differences were observed in AST,ALT,ALP,and TBA across the four groups(P>0.05).However,the GGT levels in the control group,low load group,medium load group,and high load group were(10.28±2.69)U/L,(15.64±3.13)U/L,(18.56±3.22)U/L,and(23.77±4.17)U/L,respectively.While the percentages of NK cells were(4.87±1.04)%,(6.14±1.15)%,(13.55±2.33)%,(19.84±3.27)%,respectively.A postive correlation was noted between increasing HCMV DNA load and elevated levels of GGT and NK cells(P<0.05).Correlation analysis revealed that while,AST,ALT,ALP,and TBAdid not show significant correlation with HCMV DNA(P>0.05),NK cells and GGT levels were positively correlated with HCMV DNA levels(P<0.05).Conclusion In pediatric patients with active HCMV infection,the levels of NK cells and GGT demonstrate a correlation with HCMV DNA load,while the detection of HCMV DNA aids in diagnosing active HCMV infection,it is not a reliable indicator for assessing the disease′s severity.

关 键 词：巨细胞病毒 自然杀伤细胞 Γ-谷氨酰转肽酶 人巨细胞病毒核酸 

分 类 号：R725.1[医药卫生—儿科]