低能量激光治疗女性雄激素性脱发的大样本回顾性研究  

A large sample retrospective study of low-level laser therapy for female androgenetic alopecia

作　　者：张嘉显 李昊阳 高智雍 苗勇[1] 樊哲祥 ZHANG Jiaxian;LI Haoyang;GAO Zhiyong;MIAO Yong;FAN Zhexiang(Department of Plastic and Aesthetic Surgery,Nanfang Hospital of Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院整形美容外科,广东广州510515

出　　处：《中国美容整形外科杂志》2024年第1期1-4,14,共5页Chinese Journal of Aesthetic and Plastic Surgery

基　　金：2022年广州市科技计划(k30617055)。

摘　　要：目的探究低能量激光(low-level laser therapy,LLLT)治疗女性雄激素性脱发(female androgenetic alopecia,FAGA的长期有效性及安全性。方法回顾性分析自2018年4月至2023年4月,南方医科大学南方医院整形美容外科采用LLLT治疗女性雄激素性脱发患者的临床资料,评价其疗效情况,并通过有序Logistic回归分析探讨整体疗效的相关因素。结果共纳入2418例女性雄激素性脱发患者完整资料,1207例(49.9%)达到轻微有效,767例(31.7%)达到显著有效。年龄41~50岁[OR值=1.33,95%CI(1.01,1.75)]、>50岁[OR值=1.72,95%CI(1.15,2.56)],LLLT治疗次数>180次[OR值=1.39,95%CI(1.14,1.69)],联合使用米诺地尔[OR值=1.75,95%CI(1.50,2.04)]的患者整体疗效较好;头皮屑较多[OR值=0.78,95%CI(0.63,0.96)]的患者整体疗效较差;所有患者均未出现严重不良反应。结论LLLT是一种安全有效治疗女性雄激素性脱发的疗法,建议患者长期规律使用,且联合使用米诺地尔疗效更佳。Objective To explore the long-term efficacy and safety of low-level laser therapy for female androgenetic alopecia.Methods From April 2018 to April 2023,data on female androgenic alopecia treated with low-level laser therapy were collected to evaluate the efficacy.Ordinal logistic regression analysis was used to explore the related factors of the overall efficacy.Results A total of2418 female androgenetic alopecia patients were included in this study.Totally 1207(49.9%)patients treated with low-level laser therapy had a mild effect,and 767(31.7%)patients had a significant effect.And 41 to 50 years old patients[OR=1.33,95%CI(1.01,1.75)],>50 years old patients[OR=1.72,95%CI(1.15,2.56)],LLLT use times>180[OR=1.39,95%CI(1.14,1.69)],combination with minoxidil[OR=1.75,95%CI(1.50,2.04)]had a better overall effect.Patients with more scalp dandruff[OR=0.78,95%CI(0.63,0.96)]had a poor overall effect.None of the patients had serious adverse reactions.Conclusion Low-level laser therapy is a safe and effective treatment for female androgenetic alopecia patients.Long-term regular use of low-level laser in combination with minoxidil is more effective in the treatment of female androgenetic alopecia.

关 键 词：女性雄激素性脱发 女性型脱发 低能量激光 疗效评估 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]