糖尿病足相关蛋白质组学的研究进展  

Research progress of proteomics related to diabetic foot

作　　者：周舒婕 赵玲[1] 朱方灵 柯亭羽[1] ZHOU Shujie;ZHAO Ling;ZHU Fangling(Department of Endocrinology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650106,China)

机构地区：[1]昆明医科大学第二附属医院内分泌科,650106

出　　处：《中国糖尿病杂志》2024年第2期137-140,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(82201475);昆明医科大学硕士研究生创新基金项目(2023S089)。

摘　　要：糖尿病足(DF)是DM严重慢性并发症,是DM患者致残、致死的主要原因。生物体组织器官及循环中蛋白质的变化可作为疾病发生发展的微观反映,蛋白质组学是探讨疾病发生及治疗,寻找潜在治疗靶点及预后生物标志物的重要技术。本文综述DF相关蛋白质组学的研究进展。Diabetic foot(DF)is one of the most severe chronic complications of diabetes mellitus(DM),and it is an important cause of disability and mortality inpatients with DM.Changes in proteins in the tissues,organs and circulation of organisms can serve as microscopic reflections of the disease development process.Proteomics is an important technologyto explore the pathogenesis and treatment mechanism of disease,and to find potential therapeutic targets and prognostic biomarkers of diseases.This article reviews the progress of proteomics research in DF.

关 键 词：糖尿病足 蛋白质组学 生物标志物 

分 类 号：R587.2[医药卫生—内分泌]