帕罗西汀联合安非他酮致5-羟色胺综合征2例  

Two cases of serotonin syndrome caused by paroxetine combined with bupropion

作　　者：刘小溪 袁勇贵[2] Liu Xiaoxi;Yuan Yonggui(Department of Mental Health,Linyi Central Hospital,Linyi 276400,China;Department of Psychosomatic and Psychiatry,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]临沂市中心医院精神卫生科,临沂276400 [2]东南大学附属中大医院心理精神科,南京210009

出　　处：《中华精神科杂志》2024年第2期105-107,共3页Chinese Journal of Psychiatry

摘　　要：5-羟色胺综合征(serotonin syndrome,SS)是一种少见的、由于药物及其相互作用产生的中枢和外周神经系统5-HT过多所致的药物副反应综合征,多见于使用5-HT能药物,或单胺氧化酶抑制剂(monoamine oxidase inhibitors)联用5-HT能药物后出现。因该综合征进展快,重症可致死亡,现报道2例帕罗西汀联用安非他酮后导致SS患者的诊疗经过,以提醒临床医生在联用此类药物时应注意识别早期症状,避免发生严重后果。Serotonin syndrome(SS)is an infrequent drug-induced syndrome resulting from excessive 5-HT levels in the central and peripheral nervous system due to drug administration and interactions,commonly observed following the utilization of 5-HTergic drugs or concurrent use of monoamine oxidase inhibitors(MAOI)with 5-HTergic agents.There is a case report on the management of two patients with SS who received combination therapy of paroxetine and bupropion.Given its rapid progression and potential fatality in severe instances,healthcare professionals are reminded to promptly recognize early symptoms and mitigate serious consequences when co-administering such medications.

关 键 词：帕罗西汀 安非他酮 5-羟色胺综合征 

分 类 号：R969[医药卫生—药理学]