妊娠期糖尿病患者血脂变化及对妊娠结局的影响  

Changes of blood lipids in patients with gestational diabetes mellitus and their effects on pregnancy outcomes

作　　者：曹燕 Cao Yan(Department of Obstetrics and Gynecology,Danyang People's Hospital,Zhenjiang 212300,China)

机构地区：[1]丹阳市人民医院妇产科,江苏镇江212300

出　　处：《实用妇科内分泌电子杂志》2023年第27期55-57,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的 探讨妊娠期糖尿病患者血脂变化及对妊娠结局的影响。方法 选取186例妊娠期糖尿病患者作为研究组;另选取同期正常产检的187名健康孕妇作为对照组。两组分别在孕中期、孕晚期检测血脂水平,比较两组各时期的血脂水平及妊娠结局。结果 研究组孕中期的总胆固醇(TC)、甘油三酯(TG)水平均较对照组高,且低密度脂蛋白胆固醇(LDL-C)水平较对照组低(P<0.05),高密度脂蛋白胆固醇(HDL-C)指标比较差异无统计学意义(P>0.05);研究组孕晚期的TC、TG水平均高于对照组,其HDL-C(1.39±0.33)mmol/L、LDL-C(1.35±0.37)mmol/L水平分别低于对照组的(1.68±0.43)mmol/L、(1.94±0.52)mmol/L(P<0.05)。研究组患者的早产率、剖宫产率、巨大儿率、胎膜早破率、新生儿低血糖率与新生儿窒息率均较对照组高(P<0.05)。结论 随着妊娠时间的延长,妊娠期糖尿病患者血脂水平会出现明显异常,且影响妊娠结局,临床应加强血脂水平监测并控制,从而改善妊娠结局。Objective To investigate the changes of blood lipids in patients with gestational diabetes mellitus and its influence on pregnancy outcome.Methods 186 patients with gestational diabetes were selected as the study group.A total of 187 healthy pregnant women with normal birth during the same period were selected as the control group.The blood lipid levels of the two groups were detected in the second and third trimesters respectively,and the blood lipid levels and pregnancy outcomes of the two groups were compared in each period.Results The levels of total cholesterol(TC) and triglycerides(TG) in the study group were higher than those in the control group,and the level of low-density lipoprotein cholesterol(LDL-C) was lower than that in the control group(P<0.05),and there was no statistical difference in the index of high-density lipoprotein cholesterol(HDL-C)(P>0.05).The levels of TC and TG in the study group were higher than those in the control group.The levels of HDL-C(1.39±0.33) mmol/L and LDL-C(1.35±0.37) mmol/L were lower than those of control group(1.68±0.43) mmol/L and(1.94±0.52) mmol/L,respectively(P<0.05).The rates of premature delivery,cesarean section,macrosomia,premature rupture of membranes,neonatal hypoglycemia and neonatal asphyxia in the study group were higher than those in the control group(P<0.05).Conclusion With the prolonging of pregnancy time,the blood lipid level of gestational diabetes patients will be significantly abnormal,and affect the pregnancy outcome.Clinical monitoring and control of blood lipid level should be strengthened to improve the pregnancy outcome.

关 键 词：妊娠期糖尿病 孕晚期 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]