Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors  

作　　者：Matthew Halma 

机构地区：[1]EbMCsquared CIC,Bath BA24BL,United Kingdom

出　　处：《Infectious Diseases & Immunity》2024年第1期35-40,共6页感染性疾病与免疫（英文）

摘　　要：The outbreak of SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has been influenced by the human response to the virus.These responses have undoubtedly impacted the evolutionary dynamics of the virus in ways distinct from a scenario lacking a widespread response.Two important pharmaceutical interventions,vaccination and the utilization of medications,particularly molnupiravir,known to have mutagenic properties,were the focus of this article.The impact of molnupiravir on human health was evaluated through 3 mechanisms:viral resistance,mutagenesis of SARS-CoV-2,and mutagenesis occurring in patients undergoing treatmentwithmolnupiravir.Thesemechanisms,as well as the impact of vaccination,have inadvertently given rise to unforeseen challenges in the management of the COVID-19 crisis.Taking a systems view in future pandemic responses,and taking into account the evolution of the pandemic virus,may be critical to ending the pandemic at an earlier date.

关 键 词：COVID-19 SARS-CoV-2 EVOLUTION Spike protein Molnupiravir MUTAGENESIS 

分 类 号：R563.1[医药卫生—呼吸系统]