西沙软珊瑚Lemnalia sp.倍半萜类次级代谢产物研究  

Studies on secondary metabolites of sesquiterpenoids from a Xisha soft coral Lemnalia sp.

作　　者：符安冉 肖丽 唐旭利[2] 李国强[1] FU Anran;XIAO Li;TANG Xuli;LI Guoqiang(Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;College of Chemistry and Chemical Engineering,Ocean University of China,Qingdao 266100,China)

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,医药学院,山东青岛266003 [2]中国海洋大学化学化工学院,山东青岛266100

出　　处：《中国海洋药物》2024年第1期54-59,共6页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(U2006204,41776136,41776136,2181101213,81991522)资助。

摘　　要：目的 对采自西沙群岛的软珊瑚样品Lemnalia sp.进行倍半萜类次级代谢产物的研究。方法 利用薄层色谱、硅胶柱层析、中压制备液相色谱和高效液相色谱等方法,对软珊瑚浸膏进行分离、纯化;通过核磁共振波谱和质谱等方法并结合相关文献数据比对,鉴定所分离化合物的结构。结果 从西沙群岛软珊瑚Lemnalia sp.中分离鉴定得到10个倍半萜类化合物,分别为lemnardosinane D (1)、flavalin E (2)、paralemnolin R (3)、pathylactone A (4)、(+)-13-hydroxy-aristlone (5)、laevinone A (6)、(+)-curcudiol (7)、oplodiol (8)、6-eudesmene-1β,4β-diol (9)、paralemnolide A (10)。结论 从软珊瑚Lemnalia sp.中分离得到10个已知的倍半萜类化合物,其化学结构类型分别属于nardosinane型、nornardosinane型、aristolane型、neolemnane型、bisabolane型、eudesmane型和bisnorsesquiterpene型,其中化合物4、5、7~10是首次在该属软珊瑚中发现的倍半萜。Objective To investigate the chemical structures of sesquiterpenoids isolated from a soft coral Lemnalia sp.collected from the Xisha islands.Methods The compounds in the soft coral crude extract were isolated and purified by TLC,silica gel column chromatography,MPLC and HPLC.Their structures were elucidated on the basis of NMR and MS spectroscopic data and by comparison with the data of literature.Results Ten sesquiterpenoids were isolated from Lemnalia sp.and were identified as lemnardosinane D(1),flavalin E(2),paralemnolin R(3),pathylactone A(4),(+)-13-hydroxy-aristlone(5),laevinone A(6),(+)-curcudiol(7),oplodiol(8),6-eudesmene-1β,4β-diol(9),paralemnolide A(10).Conclusion Ten known sesquiterpenoids with nardosinane,nornardosinane,aristolane,neolemnane,bisabolane,eudesmane and bisnorsesquiterpene-type skeletons were isolated from a soft coral Lemnalia sp..Compounds 4、5、7-10 were obtained from soft corals of the genus Lemnalia for the first time.

关 键 词：Lemnalia sp. 倍半萜 次级代谢产物 

分 类 号：R931.77[医药卫生—生药学]