日本立克次体与日本斑点热:病原体与疾病综述  

Rickettsia japonica and Japanese spotted fever:A review on the pathogen and disease

作　　者：王晓旭 梁莹[2] 尚猛 王璐[1,2] 姜宛均 冀好强 刘起勇 WANG Xiao-xu;LIANG Ying;SHANG Meng;WANG Lu;JIANG Wan-jun;JI Hao-qiang;LIU Qi-yong(School of Public Health,Shandong University,Ji'nan,Shandong 250102,China;National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease,Department of Vector Biology and Control,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]山东大学公共卫生学院,山东济南250102 [2]中国疾病预防控制中心传染病预防控制所媒介生物控制室,传染病溯源预警与智能决策全国重点实验室,北京102206

出　　处：《中国媒介生物学及控制杂志》2024年第1期128-131,共4页Chinese Journal of Vector Biology and Control

基　　金：国家重点研发计划(2020YFC1200101)。

摘　　要：日本斑点热(JSF)作为一种易被忽视的传染病,误诊和延误治疗是JSF患者不良预后的重要原因。该文对其病原体日本立克次体的遗传进化特征、传播途径及宿主和JSF的流行病学、临床表现、实验室检测及应对措施进行综述。尽管我国对该自然疫源性疾病的研究取得了一定的进展,但是目前还缺乏全国范围内媒介蜱类和JSF的分布信息,为此需加强全国JSF的流行病学调查和其宿主、媒介生物的监测,为该病的预防控制和临床诊断提供依据。Japanese spotted fever(JSF)is a commonly neglected infectious disease,and misdiagnosis and treatment delay are pivotal determinants of adverse outcomes among JSF patients.This paper reviews the genetic and evolutionary characteristics,transmission routes,and hosts of the pathogen Rickettsia japonica as well as the epidemiology,clinical manifestations,laboratory examination,and response strategy of JSF.Although progress has been made in the epidemiological study of this deadly infectious disease in China,information on the nationwide distribution of JSF and tick vectors is lacking.It is necessary to strengthen epidemiological investigation of JSF and surveillance of the hosts and vectors across the country,so as to provide a basis for the prevention and control and clinical diagnosis of the disease.

关 键 词：日本立克次体 日本斑点热 流行病学 现状研究 

分 类 号：R376[医药卫生—病原生物学] R183[医药卫生—基础医学]