MASP家族表达水平与脓毒症患者不良预后风险的相关性  

Correlation between MASP family expression levels and risk of poor prognosis in patients with sepsis

作　　者：冼丽娜 邓小彦 陈伟[1] XIAN Lina;DENG Xiaoyan;CHEN Wei(Department of Critical Care Medicine,the First Affiliated Hospital of Hainan Medical College,Haikou,570102,China)

机构地区：[1]海南医学院第一附属医院重症医学科,海口570102

出　　处：《临床急诊杂志》2024年第1期19-23,共5页Journal of Clinical Emergency

基　　金：海南省卫生健康行业科研项目(No:21A200050)。

摘　　要：目的:对甘露聚糖结合凝集素相关丝氨酸蛋白酶(mannan-binding lectin associated serine proteases,MASP)家族表达水平与脓毒症患者预后风险的相关性进行分析。方法:将2018年1月—2022年12月于海南医学院第一附属医院诊治的113例脓毒症患者纳入研究,所有患者入院后均予补液、抗感染等规范化治疗,根据患者纳入研究28 d内是否死亡,将患者分为死亡组及存活组,比较两组患者一般临床资料及实验室指标,采用多因素logistic回归模型分析影响患者预后的因素,并对MASP家族表达水平与急性生理与慢性健康评分(acute physiology and chronic health evaluation,APACHEⅡ)评分相关性进行分析。结果:死亡组患者APACHEⅡ评分[(27.17±2.89)分]、白细胞[(15.34±2.11)×10^(9)/L]、超敏C反应蛋白[(26.19±3.87)mg/L]、MASP-1[(4076.48±114.78)ng/L]、MASP-2[(58.75±6.31)ng/L]及MASP-3[(349.86±61.37)ng/L]水平显著高于存活组[(25.51±2.36)分,(14.23±1.64)×10^(9)/L,(28.36±3.92)mg/L,(3848.65±89.24)ng/L,(48.22±3.54)ng/L,(216.93±54.74)ng/L],差异有统计学意义(均P<0.05);白蛋白水平[(20.34±2.34)g/L]显著低于存活组[(24.78±2.61)g/L],差异有统计学意义(P<0.001);多因素logistic回归分析示,高MASP-1水平(OR=1.019,P=0.019,95%CI:1.003~1.036)、MASP-2(OR=1.557,P=0.019,95%CI:1.078~2.306)及MASP-3(OR=1.033,P=0.047,95%CI:1.000~1.066)水平是影响患者预后的独立危险因素;Peason相关分析示:MASP-1、MASP-2及MASP-3水平与APACHEⅡ评分呈正相关(R=0.792,0.763,0.511,均P<0.001)。结论:MASP家族表达水平升高与脓毒症患者不良预后呈显著正相关。Objective To analyze the correlation between the expression level of mannan-binding lectin associated serine proteases(MASP)family and the risk of poor prognosis of patients with sepsis.Methods One hundred and thirteen patients with sepsis diagnosed and treated in the First Affiliated Hospital of Hainan Medical College from January 2018 to December 2022 were included in the study.All patients were given standardized treatment such as fluid infusion and anti-infection after admission.According to whether the patients died within 28 days,they were divided into death group and survival group.Comparing the general clinical data and laboratory indexes such as MASP family expression levels of the two groups,and the multivariate logistic regression model was used to analyze the factors affecting the prognosis of the patients and the correlation between the expression level of MASP family and acute physiology and chronic health evaluation(APACHEⅡ)score.Results The level of APACHEⅡ score,white blood cell,hypersensitive C-reactive protein,MASP-1,MASP-2 and MASP-3 in the death group were significantly higher than that in the survival group(27.17±2.89)scores,(15.34±2.11)×10^(9)/L,(26.19±3.87)mg/L,(4076.48±114.78)ng/L,(58.75±6.31)ng/L,(349.86±61.37)ng/L vs.(25.51±2.36)scores,(14.23±1.64)×10^(9)/L,(28.36±3.92)mg/L,(3848.65±89.24)ng/L,(48.22±3.54)ng/L,(216.93±54.74)ng/L,all P<0.05.While the level of albumin in the death group were significantly lower than those in the survival group(20.34±2.34)g/L vs.(24.78±2.61)g/L,P<0.001.Multivariate logistic regression analysis showed that the high level of MASP-1(OR=1.019,P=0.019,95%CI:1.003-1.036)、MASP-2(OR=1.557,P=0.019,95%CI:1.078-2.306)and MASP-3(OR=1.033,P=0.047,95%CI:1.000-1.066)were independent risk factors which affecting the prognosis of patients.Pearson correlation analysis showed that the levels of MASP-1,MASP-2 and MASP-3 were positively correlated with APACHEⅡscore(R=0.792,0.763,0.511,all P<0.001).Conclusion The increased expression of MASP family is po

关 键 词：脓毒症 甘露聚糖结合凝集素相关丝氨酸蛋白酶 表达水平 不良预后 相关性 

分 类 号：R459.7[医药卫生—急诊医学]