增生性瘢痕体内外模型研究进展  

Research Progress of Hypertrophic Scar in Vivo and in Vitro Models

作　　者：朱孟锦 甘孟杰 陈傲 李凤歌 汤諹[1] ZHU Mengjin;GAN Mengjie;CHEN Ao;LI Fengge;TANG Yang(Department of Dermatology and Venereal Diseases,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院皮肤病与性病学科,云南昆明650032

出　　处：《中国皮肤性病学杂志》2024年第2期231-236,共6页The Chinese Journal of Dermatovenereology

基　　金：云南省基础研究计划重点项目(202201AY070001-039);云南省应用基础研究项目[2017FE468(-049)]。

摘　　要：增生性瘢痕(hypertrophic scar,HS)又称肥厚性瘢痕,是真皮或深层组织受损后,由过度增生的新结缔组织修复而成的皮肤损伤,属于病理性瘢痕。增生性瘢痕常形成于手术创面、裂伤、烧伤处或有炎症和感染性皮肤问题(如痤疮、毛囊炎、水痘和疫苗接种)的部位等,由于创面的异常愈合而形成,其特点为胶原蛋白大量积聚和组织纤维化增加。国内外已对增生性瘢痕进行了广泛、深入的研究,然而其形成的分子机制尚不完全清楚,仅通过研究患者皮损标本无法探索增生性瘢痕的发病机制及其进展中的组织病理变化。因此,建立合适的体内、外模型,研究增生性瘢痕的发病机制,有助于寻求有效的治疗方案。Hypertrophic scar(HS),a kind of pathological scar,is repaired by new connective tissue after deep tissue or dermis damage.It is often formed in surgical wounds,lacerations,burns or areas with inflammatory or infectious skin problems(such as acne,folliculitis,chickenpox and vaccination).Hypertrophic scar is formed by abnormal wound healing,which is characterized by large accumulation of collagen and increased tissue fibrosis.It has been widely researched all over the world,but the molecular mechanism of its is not completely clear.It is impossible to explore the pathogenesis and histopathological changes of hypertrophic scar only through the study of patient specimens.Therefore,an effective treatment for hypertrophic scar can be found by establishing appropriate models in vivo and in vitro and studying the pathogenesis of hypertrophic scar.

关 键 词：病理性瘢痕 增生性瘢痕 体内模型 体外模型 

分 类 号：R751[医药卫生—皮肤病学与性病学]