双歧杆菌活菌辅助蒙脱石散对轮状病毒感染性腹泻患儿症状改善和细胞免疫的影响  

Effect of Bifidobacterium Live-assisted Montmorillonite Powder on Symptom Improvement and Cellular Immunity in Children with Rotavirus Infectious Diarrhea

作　　者：查秀英 吴焕婷 袁光华 ZHA Xiu-ying;WU Huan-ting;YUAN Guang-hua(Pediatrics of Puyang Maternal and Child Health Hospital,Puyang 457000,Henan Province,China)

机构地区：[1]濮阳市妇幼保健院儿科,河南濮阳457000

出　　处：《罕少疾病杂志》2024年第3期82-84,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨双歧杆菌活菌辅助蒙脱石散对轮状病毒感染性腹泻患儿患儿症状改善和细胞免疫的影响。方法本文中共纳入90例轮状病毒感染性腹泻患儿,均来源于濮阳市妇幼保健院,选取时间为2020年9月至2022年9月,进行回顾性分析,将所有患儿按照治疗方法的不同分为A组(45例,单纯采用蒙脱石散治疗)和B组(45例,在A组患儿的前提下应用双歧杆菌四联活菌片治疗)。两组患儿均进行为期7 d的治疗。将两组患儿各项症状改善情况进行对比,将两组患儿免疫功能进行检测并对比,以及治疗前后肠道菌群数量和不良反应。结果B组患儿大便次数恢复正常、体温恢复时间等均比A组缩短(均P<0.05);治疗后两组患儿免疫球蛋白G(IgG)、免疫球蛋白A(IgA)及CD4+/CD8+比值均比治疗前上升,且B组患儿上述指标相较于A组上升(均P<0.05);治疗后B组患儿双歧杆菌、乳杆菌与治疗前比均增多,与A组比较增多,大肠埃希菌均相较于治疗前减少,与A组比较减少(均P<0.05);将两组患儿恶心、便秘等的总发生率,无明显差异(均P>0.05)。结论在对轮状病毒感染性腹泻患儿治疗时,将双歧杆菌四联活菌片与蒙脱石散联合,可促进患儿各项临床症状快速改善,纠正与调节免疫功能和肠道菌群紊乱,且不会增加不良反应的发生,安全性较好。Objective To investigate the effect of mormorillonite powder on symptom improvement and cellular immunity in children with rotavirus infectious diarrhea.Methods The article in 90 cases of rotavirus infection diarrhea children,all derived from the maternal and child health care of Puyang city,select time for September 2020 to September 2022,retrospective analysis,all children according to the treatment is divided into group A(45 cases,pure montmorillonite treatment)and group B(45 cases,under the premise of group A children with bifidobacteria tetrate treatment).Both groups were treated for 7 d.The improvement of symptoms in the two groups was compared,the immune function indicators of the two groups were tested and compared,and the number of intestinal flora before and after treatment and the occurrence of adverse reactions in the two groups were compared.Results The stools of group B and the recovery time were shorter than group A(P<0.05);After treatment,immunoglobulin G(IgG),IgG A(IgA)and CD4+/CD8+ratios were higher than before treatment,In addition,the above indicators of children in group B increased compared with group A(all P<0.05);The children in group B increased bifidobacteria and Lactobacillus before treatment,And group B children more bifidobacterium,Lactobacillus than group A,Escherichia coli was uniformly reduced compared to pre-treatment,Children in group B were less than those in group A(all P<0.05);The ison of adverse reactions such as nausea and constipation in the two groups,No significant difference(all P>0.05).Conclusion In the treatment of children with rotavirus infectious diarrhea,bifidobacterium quadruple live tablets and montmorillonite powder can promote the rapid improvement of clinical symptoms in children,correct and regulate immune dysfunction and intestinal flora disorder,and will not increase the occurrence of adverse reactions,and the safety is good.

关 键 词：双歧杆菌活菌 蒙脱石散 轮状病毒感染性腹泻 症状改善 细胞免疫 影响 

分 类 号：R725.7[医药卫生—儿科]