糖尿病周围神经病变多模态MRI研究进展  

Progress in multimodal MRI study of diabetic peripheral neuropathy

作　　者：王丽芹[1] 曹丹娜[2] 高兆虹 胡婧 高胜兰 李晓陵[2] WANG Liqin;CAO Danna#;GAO Zhaohong;HU Jing;GAO Shenglan;LI Xiaoling(Nursing Teaching and Research Section,First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of CT&MR,First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Nursing Teaching and Research,First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Graduate School of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院护理教研室,哈尔滨150040 [2]黑龙江中医药大学附属第一医院CT磁共振科,哈尔滨150040 [3]黑龙江中医药大学附属第一医院护理教研部,哈尔滨150040 [4]黑龙江中医药大学研究生院,哈尔滨150040

出　　处：《磁共振成像》2024年第1期211-216,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金面上项目(编号:82074537);黑龙江省自然科学基金联合引导项目(编号:LH2020H103、LH2021H101);黑龙江中医药优秀创新人才支持计划资助项目(编号:2018RCD02)。

摘　　要：糖尿病周围神经病变(diabetes peripheral neuropathy,DPN)是较常见的糖尿病慢性并发症,严重影响患者生活质量。DPN发病机制比较复杂,目前研究表明与神经病理性改变关系密切。近些年多模态MRI获得长足进展,MRI以软组织分辨率高、无创、无辐射等优点著称,成为探索DPN中枢神经及周围神经发病机制的重要方法。本文应用基于体素的形态学测量(voxel-based morphometry,VBM)、弥散张量成像(diffusion tensor imaging,DTI)、功能MRI(functional MRI,fMRI)等技术,对研究DPN脑结构、脑功能改变以及周围神经结构异常的文献进行综述,为临床早期诊断和制订精准治疗方案提供依据。Diabetes peripheral neuropathy(DPN)is a relatively common chronic complication of diabetes mellitus,which seriously affects the quality of life of patients.The pathogenesis of DPN is complex,and current studies have shown that it is closely related to neuropathic changes.In recent years,multimodal magnetic resonance imaging(MRI)has achieved long progress.MRI is famous for its high soft tissue resolution,non-invasive,non-radiation,and has become an important method to explore the pathogenesis of central and peripheral nerves in DPN.In this paper,voxel-based morphometry(VBM),diffusion tensor imaging(DTI),and functional MRI(fMRI)are applied to review the literature on the study of DPN brain structure,brain function changes,and peripheral nerve structure abnormalities.The literature on DPN brain structure,brain function changes,and peripheral nerve structure abnormalities will be reviewed to provide a basis for early clinical diagnosis and precise treatment plans.

关 键 词：糖尿病周围神经病变 磁共振成像 多模态 结构磁共振成像 功能磁共振成像 弥散张量成像 磁共振波谱成像 灌注加权成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R781.64[医药卫生—诊断学] R745[医药卫生—临床医学]