铁稳态失调与肌少症相关机制  

Mechanisms linking dysregulation of iron homeostasis to sarcopenia

作　　者：王奕哲 赵国阳[2] 杨佳茹 WANG Yi-zhe;ZHAO Guo-yang;YANG Jia-ru(The First Clinical Medical College,Jiangsu University,Zhenjiang 212001,Jiangsu,China;Department of Joint Surgery,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,Jiangsu,China)

机构地区：[1]江苏大学第一临床医学院,江苏镇江212001 [2]江苏大学附属医院关节外科,江苏镇江212001

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2023年第6期603-608,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：江苏省卫健委科研项目(M2022119);骨质疏松和骨矿盐疾病中青年医生优才培养计划(G-X-2019-1107);江苏省大学生创新创业训练计划(202210299014Z)。

摘　　要：肌少症的病因很多,发病机制复杂。近年研究显示,铁稳态失调,铁过载或者铁缺乏,均可促进肌少症的发生或发展,相关机制涉及氧化应激、线粒体、自噬、铁死亡、胰岛素抵抗和脂代谢等多种途径。本文就近年来铁稳态失调与肌少症相关机制的研究进行综述,以期为临床上肌少症的诊断和治疗提供新的思路和靶点。There are many causes of sarcopenia,and the disease mechanism is complex.Recent studies have shown that dysregulation of iron homeostasis,iron overload or iron deficiency can promote the occurrence or development of sarcopenia,with related mechanisms including oxidative stress,mitochondria,autophagy,iron death,insulin resistance,and lipid metabolism.This article reviews recent studies on the mechanism of dysregulation of iron homeostasis and sarcopenia,providing a new idea and target for the diagnosis and treatment of sarcopenia.

关 键 词：铁代谢 铁过载 铁缺乏 肌少症 

分 类 号：R58[医药卫生—内分泌] R592[医药卫生—内科学]