口腔鳞状细胞癌患者炎症指标分析  

Analysis of inflammatory indicators in patients with oral squamous cell carcinoma

作　　者：包振英 王雅杰[1] BAO Zhenying;WANG Yajie(Department of Clinical Laboratory,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Peking University School and Hospital of Stomatology,Beijing 100081,China)

机构地区：[1]首都医科大学附属北京地坛医院检验科,北京100015 [2]北京大学口腔医学院·口腔医院,北京100081

出　　处：《预防医学》2024年第3期247-250,共4页CHINA PREVENTIVE MEDICINE JOURNAL

摘　　要：目的分析口腔鳞状细胞癌(OSCC)患者炎症指标,为OSCC早期筛查和识别提供参考。方法选择北京大学口腔医院就诊的OSCC患者86例、慢性牙周炎(CP)患者61例和无上述疾病者71人分别纳入OSCC组、CP组和对照组,检测外周血降钙素原(PCT)、淀粉样蛋白A(SAA)、C反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞百分数(NEUT%)、中性粒细胞和淋巴细胞比值(NLR)、淋巴细胞和单核细胞比值(LMR)及血小板计数和淋巴细胞比值(PLR)。采用受试者操作特征(ROC)曲线评价炎症指标对OSCC的筛查效果。结果OSCC组男性46例,女性40例,年龄M(QR)为59.50(18.25)岁;CP组男性32例,女性29例,年龄M(QR)为53.00(14.50)岁;对照组男性36人,女性35人,年龄M(QR)为54.00(16.00)岁。与对照组和CP组比较,OSCC组PCT、SAA、CRP、WBC、NEUT%、NLR和PLR升高,LMR降低,差异有统计学意义(均P<0.05)。PCT、SAA和CRP联合鉴别OSCC组与对照组的效果较好,ROC曲线下面积(AUC)为0.992,大于8项指标单独鉴别(均P<0.05);PCT、WBC和NLR联合鉴别OSCC组与CP组的效果较好,AUC值为0.841,大于WBC、LMR和PLR单独鉴别(均P<0.05)。结论与CP患者、无OSCC和CP者比较,OSCC患者炎症指标水平存在明显差异,可能有助于OSCC早期识别。Objective To examine the inflammatory indicators in patients with oral squamous cell carcinoma(OSCC),so as to provide insights into early screening and recognition of OSCC.Methods A total of 86 OSCC patients,61 pa⁃tients with chronic periodontitis(CP)and 71 patients without the above diseases were selected from Peking University Hospital of Stomatology and were enrolled in the OSCC group,CP group and control group.Procalcitonin(PCT),serum amyloid A(SAA),C-reactive protein(CRP),white blood cell count(WBC),neutrophil percentage(NEUT%),neutrophil to lymphocyte ratio(NLR),lymphocyte to monocyte ratio(LMR),platelet count and lymphocyte ratio(PLR)were mea⁃sured in peripheral blood.Receiver operating characteristic(ROC)curves were used to evaluate the effectiveness of the aforementioned inflammatory indicators in OSCC screening.Results The OSCC group consisted of 46 males and 40 fe⁃males,with a median age of 59.50(interquartile range,18.25)years;the CP group consisted of 32 males and 29 fe⁃males,with a median age of 53.00(interquartile range,14.50)years;the control group consisted of 36 males and 35 fe⁃males,with a median age of 54.00(interquartile range,16.00)years.Compared with the control group and the CP group,the PCT,SAA,CRP,WBC,NEUT%,NLR and PLR in the OSCC group were increased,and the LMR was de⁃creased,and the difference was statistically significant(all P<0.05).The combined use of PCT,SAA and CRP had a good effect in distinguishing the OSCC group from the control group,with an area under the ROC curve(AUC)of 0.992,which was higher than the individual identification of the 8 indicators(all P<0.05).The combined use of PCT,WBC,and NLR also had a good effect in distinguishing the OSCC group from the CP group,with an AUC value of 0.841,which was higher than the individual identification of WBC,LMR and PLR(all P<0.05).Conclusion Compared with patients with CP,as well as patients without OSCC and CP,patients with OSCC exhibit significant differences in inflammatory indicator levels,which may facilitate ear

关 键 词：口腔鳞状细胞癌 炎症指标 慢性牙周炎 

分 类 号：R179[医药卫生—妇幼卫生保健]