Safety and effectiveness of butorphanol in epidural labor analgesia:A protocol for a systematic review and meta-analysis  

作　　者：Guan-Cheng Tang Man He Zhen-Zhao Huang Yan Cheng 

机构地区：[1]Department of Anesthesiology,Yongkang Hospital of Traditional Chinese Medicine,Jinhua 321301,Zhejiang Province,China [2]Department of Gynecology and Obstetrics,Yongkang Hospital of Traditional Chinese Medicine,Jinhua 321301,Zhejiang Province,China [3]Department of Anesthesiology,Hangzhou United Liger Sixth Medical Beauty Hospital,Hangzhou 311215,Zhejiang Province,China [4]Department of Ultrasound,Hangzhou Women’s Hospital,Hangzhou 310008,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第8期1416-1421,共6页世界临床病例杂志

摘　　要：BACKGROUND Epidural analgesia is the most effective analgesic method during labor.Butorphanol administered epidurally has been shown to be a successful analgesic method during labor.However,no comprehensive study has examined the safety and efficacy of using butorphanol as an epidural analgesic during labor.AIM To assess butorphanol's safety and efficacy for epidural labor analgesia.METHODS The PubMed,Cochrane Library,EMBASE,Web of Science,China National Knowledge Infrastructure,and Google Scholar databases will be searched from inception.Other types of literature,such as conference abstracts and references to pertinent reviews,will also be reviewed.We will include randomized controlled trials comparing butorphanol with other opioids combined with local anesthetics for epidural analgesia during labor.There will be no language restrictions.The primary outcomes will include the visual analog scale score for the first stage of labor,fetal effects,and Apgar score.Two independent reviewers will evaluate the full texts,extract data,and assess the risk of bias.Publication bias will be evaluated using Egger's or Begg's tests as well as visual analysis of a funnel plot,and heterogeneity will be evaluated using the Cochran Q test,P values,and I2 values.Meta-analysis,subgroup analysis,and sensitivity analysis will be performed using RevMan software version 5.4.This protocol was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)Protocols statement,and the PRISMA statement will be used for the systematic review.RESULTS This study provides reliable information regarding the safety and efficacy of using butorphanol as an epidural analgesic during labor.CONCLUSION To support clinical practice and development,this study provides evidence-based findings regarding the safety and efficacy of using butorphanol as an epidural analgesic during labor.

关 键 词：Epidural analgesia during labor BUTORPHANOL SAFETY PROTOCOL META-ANALYSIS 

分 类 号：R714.3[医药卫生—妇产科学]