地塞米松注射液联合美能片治疗大鼠皮肤压迫性注射胶原蛋白导致过敏的研究  

A Study on the Treatment of Allergies Caused by Skin Compression Injection of Collagen in Rats with Dexamethasone Injection Combined with Meineng Tablets

作　　者：黄家鑫 黄冉 李宏强 HUANG Jia-xin;HUANG Ran;LI Hong-qiang(Hangzhou Biyan Philosophy health Management Co.,LTD.Jinsha Tianjie medical cosmetology clinic,Zhejiang Province,311500,China;FIMANPharmaceutical Biotechnology Co.,Ltd,Jilin Province,130012,China)

机构地区：[1]杭州碧妍哲理健康管理有限公司金沙天街医疗美容诊所,浙江杭州311500 [2]斐缦(长春)医药生物科技有限责任公司,吉林长春130012

出　　处：《中国医疗美容》2024年第2期103-107,共5页China Medical Cosmetology

摘　　要：目的探讨造成注射胶原蛋白出现皮肤过敏的原因,观察地塞米松联合美能片的治疗此类皮肤过敏的效果。方法根据不同的药物和注射操作方式,建立对照组,皮内注射组,压迫性皮内注射组以及阳性药物组。药物研究时,压迫性注射造模后分为地塞米松联合美能片给药组、地塞米松给药组、美能片给药和生理盐水对照组。造模后处死大鼠,用生理盐水冲洗腹腔收集洗涤液。然后取皮下注射位置皮肤进行病理实验。结果压迫性皮内注射组可见注射点位水肿,但水肿程度低于阳性药物组,且未见明显蓝斑。伊文思蓝结果显示阳性药物组和压迫性皮内注射组伊文思蓝渗出量显著升高(P<0.01)。病理结果显示压迫性皮内注射组真皮层可见明显疏松水肿且可见炎症细胞浸润。药物研究显示地塞米松注射液联合美能片治疗的给药组伊文思蓝渗出量虽无统计学意义,但呈降低趋势,且病理结果显示联合用药组的组织炎性细胞浸润减少。结论压迫性注射方式是造成注射胶原蛋白时出现过敏反应的可能原因,联合应用地塞米松注射液和美能片可有效改善压迫性注射所致的过敏反应。Objective To investigate the causes of skin allergy caused by the injection of and the therapeutic effect of dexamethasone combined with Meineng tablets.Methods According to difffferent drugs and injection methods,the rats were divided into 4 groups:control group,intradermal injection group,pressure injection group and positive drug group.The drug study adopted the pressure injection model which was divided into dexamethasone combined with Meineng tablet group,dexamethasone group,Meineng tablet group and normal saline control group.After the rats were killed,and the abdominal cavity was washed with normal saline to collect the washing liquid.Then the skin was taken to the subcutaneous injection site for pathological experiments.Results The pressure injection group showed edema at the injection site,but it was not as obvious as that in the positive drug group,and there was no obvious blue spot.Evans Blue showed that the exudation of Evans Blue in the positive drug group and the pressure injection group was significantly increased(P<0.01).The pathological results showed that the dermis of the pressure injection group was obviously loose and edema and inflflammatory cell infifiltration was seen.Drug study showed that although the amount of Evans Blue in the administration group treated with dexamethasone injection combined with Meineng tablets was not statistically signifificant,it showed a decreasing trend,and the pathological results showed tissue infifiltration of inflflammatory cells in the administration group reduce.Conclusion Pressure injection is a possible cause of allergic reactions when injecting collagen,and the combined application of dexamethasone injection and Meineng tablets can effffectively improve allergic reactions caused by pressure injection.

关 键 词：地塞米松 美能片 复方甘草酸苷 胶原蛋白 过敏反应 

分 类 号：R622[医药卫生—整形外科]