孤独症谱系障碍儿童磁共振波谱影像改变的对照研究  

A Comparative Study on The Changes of Thalamic and Cerebellar Metabolites in Children with Autism Spectrum Disorders

作　　者：孟婕 胡航嘉 张瑞欣 牧丰苗 姜志红[1] MENG Jie;HU Hang-jia;ZHANG Rui-xin;MU Feng-miao;JIANG Zhi-hong(The First Affiliated Hospital of Henan University of science and Technology,Luoyang 471000,Henan Province,China)

机构地区：[1]河南科技大学临床医学院·河南科技大学第一附属医院,河南洛阳471000

出　　处：《中国CT和MRI杂志》2024年第3期46-47,51,共3页Chinese Journal of CT and MRI

基　　金：河南省中国科学院科技成果转移转化项目(2018105)。

摘　　要：目的探讨孤独症谱系障碍(ASD)儿童同正常发育儿童在丘脑和小脑代谢物的变化关系。方法采用质子磁共振波谱(1H-MRS)对2-6岁ASD儿童(60例)和正常发育儿童(60例)双侧丘脑及小脑波谱分析,MRS的代谢物NAA/Cr、Cho/Cr、MI/Cr、Glx/Cr的相对值以Cr为内标测定,对比两组各代谢产物变化。结果与正常儿童相比,ASD组两侧丘脑和小脑NAA/Cr更低、双侧丘脑和左侧小脑Glx/Cr更高(P<0.05)。ASD儿童在丘脑和小脑半球之间代谢物比较,无统计学意义(P>0.05)。结论ASD儿童小脑、丘脑有代谢障碍,NAA/Cr降低和Glx/Cr增高可能同ASD的发病相关。Objective Exploring the relationship between changes in thalamic and cerebellar metabolites in children with autism spectrum disorders(ASD)and normally developing children.Methods Proton magnetic resonance spectroscopy(1H-MRS)analysis of bilateral thalamic and cerebellar wave spectra in children aged 2-6 years with ASD(60 cases)and normally developing children(60 cases).The relative values of NAA/Cr,Cho/Cr,MI/Cr and Glx/Cr were measured with Cr as internal standard,and the differences of metabolites between the two groups were compared.Results Compared with normal children,lower thalamic and cerebellar NAA/Cr on both sides of the ASD group,higher Glx/Cr in bilateral thalamus and left cerebellum(P<0.05).Comparison of metabolites between the thalamus and cerebellar hemispheres in children with ASD,not statistically significant(P>0.05).Conclusion Children with ASD have metabolic disorders in the cerebellum and thalamus.The decrease of NAA/Cr and the increase of Glx/Cr may be related to the pathogenesis of ASD.

关 键 词：孤独症谱系障碍 磁共振波谱 丘脑 小脑 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.82[医药卫生—诊断学]