基于数据挖掘的抑郁动物模型及信号通路分析  

Analysis of Animal Models and Signal Pathways of Depression Based on Data Mining

作　　者：岑潇磊 李敏 林素素 王婷 童应鹏 CEN Xiaolei;LI Min;LIN Susu;WANG Ting;TONG Yingpeng(Taizhou University,School of Medicine,School of Pharmacy,Taizhou 318000,China;Taizhou University,Medicine and Health Product,School of Pharmacy,Taizhou 318000,China;The First Hospital of Jiaxing,Affiliated Hospital of Jiaxing University,Jiaxing 314001,China)

机构地区：[1]台州学院医学院,浙江台州318000 [2]台州学院药学院/天然产物与健康产品研究所,浙江台州318000 [3]嘉兴学院附属第一医院药学部,浙江嘉兴314001

出　　处：《中国现代应用药学》2024年第4期567-582,共16页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省自然科学基金(LQ22H280014);国家自然科学基金青年基金项目(81703688);国家重点研发计划项目(2017YFE01301000);台州市社会发展科技计划项目(21ywb80);浙江省药学会医院药学专项(2020YY45)。

摘　　要：抑郁症是当今社会影响人类心理健康的一种较为常见的疾病。而抑郁动物模型的建立对抑郁症的研究具有重要意义。近年来人们对于抑郁症的研究逐渐增加,抑郁动物的造模手段也逐渐丰富。其中由于操作和成本方面的原因,对于啮齿动物的抑郁造模更为普遍和成熟。目前主流的抑郁动物模型有应激模型、药物模型、手术模型和遗传模型。各个模型各有利弊,可以根据研究目的选取合适的方法进行造模,以便后续对抑郁症进行深入的研究。近年来的研究发现,一些脑内的信号通路已经成为新的治疗抑郁症的靶点,这些信号通路与抑郁症密切相关,作用于这些靶点的药物疗效显著。因此,本文就近年来抑郁动物模型及信号通路的研究进展进行综述,为研究抑郁症发病机制提供理论依据。Depression is a common disease that affects human mental health in today’s society.The establishment of animal model of depression is of great significance to the study of depression.In recent years,people’s research on depression has gradually increased,and the modeling methods of depression animals have been gradually enriched.Due to the reasons of operation and cost,the modeling of depression in rodents is more common and mature.At present,the main animal models of depression include stress model,drug model,surgical model and genetic model.Each model has its own advantages and disadvantages.Appropriate methods can be selected according to the research purpose,so as to conduct in-depth research on depression.Recent studies have found that some brain signal pathways have become new targets for the treatment of depression.These signal pathways are closely related to depression,and the drugs acting on these targets have significant curative effects.Therefore,this paper reviewed the research progress of animal models and signal pathways of depression in recent years,so as to provide a theoretical basis for the study of the pathogenesis of depression.

关 键 词：抑郁症 动物模型 信号通路 

分 类 号：R965.1[医药卫生—药理学]