加味玉屏风颗粒联合益生菌治疗慢性自发性荨麻疹的临床疗效和安全性  

Efficacy and safety of modified Yupingfeng granules combined with probiotics in chronic spontaneous urticaria

作　　者：王宁[1] 吴春雁[1] 颜志芳[1] Ning-WANG;Chun-Yan WU;Zhi-Fang YAN(Department of Dermatology,Guang'anmen Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院皮肤科,北京100053

出　　处：《中国药师》2023年第12期442-448,共7页China Pharmacist

基　　金：中国中医科学院科技创新工程课题项目(C12021A02313)。

摘　　要：目的本研究旨在评估加味玉屏风颗粒(MYG)联合益生菌在慢性自发性荨麻疹(CSU)患者治疗中的有效性和安全性。方法纳入2021年6月至2023年6月中国中医科学院广安门医院就诊的CSU患者为研究对象。根据随机数字表法,将CUS患者分为MYG组(氯雷他定联合MYG)和MYGP组[氯雷他定联合MYG和益生菌(枯草杆菌二联活菌肠溶胶囊)]。采用荨麻疹活动性评分(UAS7)、皮肤病生活质量指数(DLQI)和中医证候评分对疗效进行评估。检测并比较治疗前后炎性因子[血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]和免疫因子(外周血CD3+、CD4+、CD8+、CD4+/CD8+水平)、IgE的水平差异。观察并比较两组治疗有效率,治疗过程中不良反应的发生情况。治疗完成3个月,比较两组患者复发情况。结果研究共纳入240例CSU患者,MYG组和MYGP组各120例。治疗后,MYGP组CSU患者USA7、DLQI、中医证候评分、IL-6、TNF-α、CD8+和IgE显著低于MYG组,而CD3+、CD4+和CD4+/CD8+显著高于MYG组(P<0.05)。MYGP组CSU患者治疗总有效率明显高于MYG组(P<0.05),而不良反应发生率和复发率显著低于MYG组(P<0.05)。结论益生菌联合MYG辅助治疗CSU疗效显著优于MYG单药辅助治疗,可显著提高治疗效果,降低炎性因子,调节免疫功能,提高生活质量,降低CSU复发率和不良反应发生率,安全性高。Objective To evaluate the efficacy and safety of modified Yupingfeng granules(MYG)combined with probiotics in the treatment of patients with chronic spontaneous urticaria(CSU).Methods Patients with CSU who attended Guang'anmen Hospital,China Academy of Chinese Medical Sciences from June 2021 to June 2023 were enrolled.According to the random number table method,CUS patients were divided into MYG group(loratadine combined with MYG)and MYGP group[loratadine combined with MYG and probiotics(live combined bacillus subtilis and enterococcus enteric-coated capsules)].The urticaria activity score(UAS7),dermatological life quality index(DLQI)and TCM pattern score were used to evaluate the efficacy.The differential levels of inflammatory factors[serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]and immune factors(peripheral blood CD3+,CD4+,CD8+,CD4+/CD8+levels),IgE were detected and compared before and after treatment.The treatment efficacy betwenen tow groups and occurrence of adverse reactions during treatment was observed and compared.Three months after the completion of treatment,the recurrence of the two groups was compared.Results A total of 240 patients with CSU were included in the study,including 120 patients in the MYG group and 120 in the MYGP group.After treatment,USA7,DLQI,TCM pattern score,IL-6,TNF-α,CD8+and IgE in the MYGP group were significantly lower than those in the MYG group,while CD3+,CD4+and CD4+/CD8+were significantly higher than those in the MYG group(P<0.05).The total effective rate of CSU patients in the MYGP group was significantly higher than that in the MYG group(P<0.05),while the incidence of adverse reactions and recurrence were significantly lower than those in the MYG group(P<0.05).Conclusion The efficacy of probiotics combined with MYG adjuvant therapy for CSU is significantly better than that of MYG monotherapy adjuvant therapy,which can significantly improve the treatment effect,reduce inflammatory factors,regulate immune function,improve quality of life,reduce the recurre

关 键 词：慢性自发性荨麻疹 益生菌 加味玉屏风颗粒 疗效 安全性 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]