益气开秘汤联合穴位埋线治疗气虚型慢性便秘的临床疗效和安全性研究  

Study on clinical efficacy and safety of Yiqi Kaimi decoction combined with acupoint catgut embedding in the treatment of chronic constipation of qi deficiency type

作　　者：张伟 魏冬梅 余春 Wei ZHANG;Dong-Mei WEI;Chun YU(Department of Spleen and Stomach Diseases,Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi’an 710002,China;Department of Outpatient,Northwest University of Political Science and Law,Xi’an 710061,China;Department of Internal Medicine,Xi'an Traditional Chinese Medicine Brain Disease Hospital,Xi’an 710032,China)

机构地区：[1]陕西省中医医院脾胃病一科,西安710002 [2]西北政法大学门诊部,西安710061 [3]西安中医脑病医院内科,西安710032

出　　处：《中国药师》2023年第12期465-471,共7页China Pharmacist

摘　　要：目的探究益气开秘汤联合穴位埋线对气虚型慢性便秘患者的临床疗效和安全性。方法纳入2022年1月至2023年6月于陕西省中医医院诊治的气虚型慢性便秘患者为研究对象,将患者分为对照组和试验组。对照组给予按常规治疗和穴位埋线,试验组在对照组的基础上给予益气开秘汤治疗。观察并比较两组患者治疗前后中医证候积分、排便性状、生活质量、血清一氧化氮(NO)和P物质(SP)含量的差异。观察患者治疗期间不良反应的发生情况,进行安全性评估。结果研究共纳入80例气虚型慢性便秘患者,试验组和对照组各40例。治疗后,试验组患者中医证候积分(排便时间、排便间隔、排便困难、腹部冷痛和四肢不温)、排便性状得分、生活质量评分低于对照组(P<0.05)。试验组血清NO低于对照组,而血清SP高于对照组(P<0.05)。治疗期间,两组患者均未出现肝肾功能明显异常、呕吐、腹泻等胃肠道不适症状,且埋线部位无异常现象。结论益气开秘汤联合穴位埋线治疗气虚型慢性便秘疗效显著,可通过调控血清NO和SP,改善患者中医证候积分、排便性状和生活质量。Objective To investigate the clinical efficacy and safety of Yiqi Kaimi decoction combined with acupoint embedding in patients with chronic constipation with qi deficiency.Methods Patients with chronic constipation with qi deficiency who were diagnosed and treated in Shaanxi Provincial Hospital of Traditional Chinese Medicine from January 2022 to June 2023 were enrolled and divided into control group and test group.The control group was given conventional treatment and acupoint embedding,and the test group was treated with Yiqi Kaimi decoction on the basis of the control group.The differences in TCM syndrome scores,defecation traits,quality of life,serum nitric oxide(NO)and substance P(SP)levels between the two groups before and after treatment were observed and compared.The occurrence of adverse reactions during the treatment of patients was observed,and safety evaluation was carried out.Results A total of 80 patients with chronic constipation with qi deficiency were included in the study,including 40 patients in the test group and 40 cases in the control group.After treatment,the TCM syndrome scores(defecation time,defecation interval,difficulty in defecation,cold pain in the abdomen and warmth in the limbs)of the test group were lower than those of the control group(P<0.05).The serum NO in the test group was lower than that in the control group,while the serum SP was higher than that in the control group(P<0.05).During the treatment,there were no obvious abnormalities in liver and kidney function,vomiting,diarrhea and other gastrointestinal discomfort symptoms in the two groups,and there was no abnormal phenomenon at the thread embedding site.Conclusion Yiqi Kaimi decoction combined with acupoint embedding has a significant effect in the treatment of qi deficiency chronic constipation,and can improve the TCM syndrome score,defecation traits and quality of life of patients by regulating serum NO and SP.

关 键 词：益气开秘汤 穴位埋线 气虚型慢性便秘 临床疗效 安全性 

分 类 号：R256.35[医药卫生—中医内科学]