1例度拉糖肽引起胰腺炎的病例分析  

A case analysis of pancreatitis caused by dulaglutide

作　　者：宦娣[1] 马静[2] 吴子静 李佳会 王瑞 李文翔[2] Di HUAN;Jing MA;Zi-Jing WU;Jia-Hui LI;Rui WANG;Wen-Xiang LI(Department of Pharmacy,Bengbu First People’s Hospital,Bengbu 233001,Anhui Province,China;Department of General surgery,Bengbu First People’s Hospital,Bengbu 233001,Anhui Province,China)

机构地区：[1]蚌埠市第一人民医院药剂科,安徽蚌埠233001 [2]蚌埠市第一人民医院普外科,安徽蚌埠233001

出　　处：《中国药师》2023年第10期140-144,共5页China Pharmacist

摘　　要：临床药师参与1例使用度拉糖肽后引起胰腺炎的治疗过程。该患者为50岁男性,既往患2型糖尿病、高血压、脑梗死多年,因突发腹痛腹胀入院,结合实验室检查结果诊断为急性胰腺炎。临床药师分析患者既往疾病史以及用药史,认为患者发生胰腺炎很可能是度拉糖肽引起的不良反应。建议临床及时停药、禁食、给予奥曲肽治疗,患者脂肪酶逐渐降至正常值,腹痛、腹胀好转。临床药师结合患者的病情和用药情况,分析药物使用与药品不良反应之间的关系,及时调整用药方案,加强了对药源性疾病的认识。Clinical pharmacists participated in the treatment process of a case of pancreatitis caused by dulaglutide.The patient was a 50-year-old male,suffered from type 2 diabetes,hypertension and cerebral infarction for many years.Due to sudden abdominal pain and abdominal distention,he was admitted to the hospital and diagnosed as acute pancreatitis according to the laboratory examination results.Clinical pharmacists analyzed the patient's past disease history and medication history,evaluated the possibility of dulaglutide causing pancreatitis.Clinical pharmacists suggested to stop taking dulaglutide at once.At the same time,the treatment of octreotide and fasting were gived.The patient's lipase gradually decreased to the normal value,and abdominal pain and abdominal distension improved.The clinical pharmacist analyzed the relationship between drug use and adverse drug reaction based on the patient's condition and medication,adjusted the medication plan in time,and strengthened the understanding of drug-induced diseases.

关 键 词：度拉糖肽 胰腺炎 药品不良反应 胰高血糖素样肽-1受体激动剂 

分 类 号：R969[医药卫生—药理学]